Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis

DNA methyltransferases (DNMTs) catalyze methylation at the C5 position of cytosine with S-adenosyl-l-methionine. Methylation regulates gene expression, serving a variety of physiological and pathophysiological roles. The chemical mechanisms regulating DNMT enzymatic activity, however, are not fully...

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Detalles Bibliográficos
Autores principales: Okuda, Kosaku, Nakahara, Kengo, Ito, Akihiro, Iijima, Yuta, Nomura, Ryosuke, Kumar, Ashutosh, Fujikawa, Kana, Adachi, Kazuya, Shimada, Yuki, Fujio, Satoshi, Yamamoto, Reina, Takasugi, Nobumasa, Onuma, Kunishige, Osaki, Mitsuhiko, Okada, Futoshi, Ukegawa, Taichi, Takeuchi, Yasuo, Yasui, Norihisa, Yamashita, Atsuko, Marusawa, Hiroyuki, Matsushita, Yosuke, Katagiri, Toyomasa, Shibata, Takahiro, Uchida, Koji, Niu, Sheng-Yong, Lang, Nhi B., Nakamura, Tomohiro, Zhang, Kam Y. J., Lipton, Stuart A., Uehara, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899281/
https://www.ncbi.nlm.nih.gov/pubmed/36739439
http://dx.doi.org/10.1038/s41467-023-36232-6

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