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ASC specks exacerbate α‑synuclein pathology via amplifying NLRP3 inflammasome activities

BACKGROUND: Inflammasome activation has a pathogenic role in Parkinson’s disease (PD). Up-regulated expressions of inflammasome adaptor apoptosis-associated speck-like protein containing a CARD (ASC) and assembly of ASC specks have been observed in postmortems of human PD brains and experimental PD...

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Detalles Bibliográficos
Autores principales:	Zheng, Ran, Yan, Yiqun, Dai, Shaobing, Ruan, Yang, Chen, Ying, Hu, Chenjun, Lin, Zhihao, Xue, Naijia, Song, Zhe, Liu, Yi, Zhang, Baorong, Pu, Jiali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899382/ https://www.ncbi.nlm.nih.gov/pubmed/36740674 http://dx.doi.org/10.1186/s12974-023-02709-w

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