Ileal signet-ring cell carcinoma with brain metastases: A case report

BACKGROUND: Signet-ring cell carcinoma (SRCC) is a rare subtype of adenocarcinoma that frequently originates in the stomach. Uncommonly, this tumor can lead to brain metastases; an event rarely reported in the literature. CASE DESCRIPTION: A 76-year-old man with a history of cognitive impairment was...

Descripción completa

Detalles Bibliográficos
Autores principales: Cabrera-Montes, Jorge, Fuel-Gómez, Daniela, Lara-Almunia, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899457/
https://www.ncbi.nlm.nih.gov/pubmed/36751443
http://dx.doi.org/10.25259/SNI_870_2022
Descripción
Sumario:BACKGROUND: Signet-ring cell carcinoma (SRCC) is a rare subtype of adenocarcinoma that frequently originates in the stomach. Uncommonly, this tumor can lead to brain metastases; an event rarely reported in the literature. CASE DESCRIPTION: A 76-year-old man with a history of cognitive impairment was diagnosed with two brain space-occupying lesions. A whole-body 18F-FDG PET/computed tomography scan revealed a hypermetabolic lesion in a segment of the ileum corresponding to mural thickening and an ulcerated lesion detected on colonoscopy. A brain biopsy, using an immunohistochemistry protocol, showed signet-ring cells with a pattern that suggested an intestinal origin. The diagnosis of SRCC brain metastases with an ileal origin was made, and a treatment protocol was designed. However, the patient rapidly deteriorated, and passed away shortly afterward. CONCLUSION: To the best of our knowledge, this is the first case report of an ileal SRCC with brain metastases.

Ejemplares similares