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Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy

The role of previous thoracic radiation therapy as a risk factor of immune‐related pneumonitis is unclear. Furthermore, some patients develop radiation recall pneumonitis, which is characterized by a radiation pneumonitis‐like imaging pattern with consolidation progressing within a previous radiatio...

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Autores principales: Noda‐Narita, Shoko, Naito, Tomoyuki, Udagawa, Hibiki, Goto, Koichi, Miyawaki, Taichi, Mamesaya, Nobuaki, Nakashima, Kazuhisa, Kenmotsu, Hirotsugu, Shimokawaji, Tadasuke, Kato, Terufumi, Hakozaki, Taiki, Okuma, Yusuke, Nakamura, Masaki, Nakayama, Yuko, Watanabe, Hirokazu, Kusumoto, Masahiko, Ohe, Yuichiro, Horinouchi, Hidehito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899626/
https://www.ncbi.nlm.nih.gov/pubmed/36285515
http://dx.doi.org/10.1111/cas.15621
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author Noda‐Narita, Shoko
Naito, Tomoyuki
Udagawa, Hibiki
Goto, Koichi
Miyawaki, Taichi
Mamesaya, Nobuaki
Nakashima, Kazuhisa
Kenmotsu, Hirotsugu
Shimokawaji, Tadasuke
Kato, Terufumi
Hakozaki, Taiki
Okuma, Yusuke
Nakamura, Masaki
Nakayama, Yuko
Watanabe, Hirokazu
Kusumoto, Masahiko
Ohe, Yuichiro
Horinouchi, Hidehito
author_facet Noda‐Narita, Shoko
Naito, Tomoyuki
Udagawa, Hibiki
Goto, Koichi
Miyawaki, Taichi
Mamesaya, Nobuaki
Nakashima, Kazuhisa
Kenmotsu, Hirotsugu
Shimokawaji, Tadasuke
Kato, Terufumi
Hakozaki, Taiki
Okuma, Yusuke
Nakamura, Masaki
Nakayama, Yuko
Watanabe, Hirokazu
Kusumoto, Masahiko
Ohe, Yuichiro
Horinouchi, Hidehito
author_sort Noda‐Narita, Shoko
collection PubMed
description The role of previous thoracic radiation therapy as a risk factor of immune‐related pneumonitis is unclear. Furthermore, some patients develop radiation recall pneumonitis, which is characterized by a radiation pneumonitis‐like imaging pattern with consolidation progressing within a previous radiation field. In this multicenter retrospective study, we analyzed the relationship of previous thoracic radiation therapy with immune‐related pneumonitis and the characteristics of radiation recall pneumonitis. The medical records of patients with non‐small‐cell lung cancer who had received nivolumab between December 2015 and March 2017 at five institutions were retrospectively reviewed. Incidence, imaging patterns, clinical course, and risk factors of immune‐related pneumonitis and radiation recall pneumonitis were evaluated. A total of 669 patients were evaluated, and the incidences of all‐grade and grade 3 or higher immune‐related pneumonitis were 8.8% and 2.6%, respectively. The incidences of immune‐related pneumonitis were 13.2% (34/257) and 6.1% (25/412) in patients with and those without previous thoracic radiation therapy, respectively. A history of previous thoracic radiation therapy was associated with immune‐related pneumonitis (odds ratio, 2.11; 95% confidence interval, 1.21–3.69 in multivariate analysis). Among the patients with previous thoracic radiation therapy, 6.2% (16/257) showed radiation recall pattern. This study found an increased risk of nivolumab‐induced immune‐related pneumonitis associated with a history of thoracic radiation therapy. Radiation recall pattern was one of the major patterns of immune‐related pneumonitis among the patients with previous thoracic radiation therapy. Incidence, risk factors, and clinical outcome of radiation recall pneumonitis were elucidated.
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spelling pubmed-98996262023-02-09 Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy Noda‐Narita, Shoko Naito, Tomoyuki Udagawa, Hibiki Goto, Koichi Miyawaki, Taichi Mamesaya, Nobuaki Nakashima, Kazuhisa Kenmotsu, Hirotsugu Shimokawaji, Tadasuke Kato, Terufumi Hakozaki, Taiki Okuma, Yusuke Nakamura, Masaki Nakayama, Yuko Watanabe, Hirokazu Kusumoto, Masahiko Ohe, Yuichiro Horinouchi, Hidehito Cancer Sci ORIGINAL ARTICLES The role of previous thoracic radiation therapy as a risk factor of immune‐related pneumonitis is unclear. Furthermore, some patients develop radiation recall pneumonitis, which is characterized by a radiation pneumonitis‐like imaging pattern with consolidation progressing within a previous radiation field. In this multicenter retrospective study, we analyzed the relationship of previous thoracic radiation therapy with immune‐related pneumonitis and the characteristics of radiation recall pneumonitis. The medical records of patients with non‐small‐cell lung cancer who had received nivolumab between December 2015 and March 2017 at five institutions were retrospectively reviewed. Incidence, imaging patterns, clinical course, and risk factors of immune‐related pneumonitis and radiation recall pneumonitis were evaluated. A total of 669 patients were evaluated, and the incidences of all‐grade and grade 3 or higher immune‐related pneumonitis were 8.8% and 2.6%, respectively. The incidences of immune‐related pneumonitis were 13.2% (34/257) and 6.1% (25/412) in patients with and those without previous thoracic radiation therapy, respectively. A history of previous thoracic radiation therapy was associated with immune‐related pneumonitis (odds ratio, 2.11; 95% confidence interval, 1.21–3.69 in multivariate analysis). Among the patients with previous thoracic radiation therapy, 6.2% (16/257) showed radiation recall pattern. This study found an increased risk of nivolumab‐induced immune‐related pneumonitis associated with a history of thoracic radiation therapy. Radiation recall pattern was one of the major patterns of immune‐related pneumonitis among the patients with previous thoracic radiation therapy. Incidence, risk factors, and clinical outcome of radiation recall pneumonitis were elucidated. John Wiley and Sons Inc. 2022-11-20 /pmc/articles/PMC9899626/ /pubmed/36285515 http://dx.doi.org/10.1111/cas.15621 Text en © 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle ORIGINAL ARTICLES
Noda‐Narita, Shoko
Naito, Tomoyuki
Udagawa, Hibiki
Goto, Koichi
Miyawaki, Taichi
Mamesaya, Nobuaki
Nakashima, Kazuhisa
Kenmotsu, Hirotsugu
Shimokawaji, Tadasuke
Kato, Terufumi
Hakozaki, Taiki
Okuma, Yusuke
Nakamura, Masaki
Nakayama, Yuko
Watanabe, Hirokazu
Kusumoto, Masahiko
Ohe, Yuichiro
Horinouchi, Hidehito
Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy
title Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy
title_full Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy
title_fullStr Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy
title_full_unstemmed Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy
title_short Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy
title_sort nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899626/
https://www.ncbi.nlm.nih.gov/pubmed/36285515
http://dx.doi.org/10.1111/cas.15621
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