A hypothermia mimetic molecule (zr17-2) reduces ganglion cell death and electroretinogram distortion in a rat model of intraorbital optic nerve crush (IONC)

Introduction: Ocular and periocular traumatisms may result in loss of vision. Our previous work showed that therapeutic hypothermia prevents retinal damage caused by traumatic neuropathy. We also generated and characterized small molecules that elicit the beneficial effects of hypothermia at normal...

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Detalles Bibliográficos
Autores principales: Contartese, Daniela S., Rey-Funes, Manuel, Peláez, Rafael, Soliño, Manuel, Fernández, Juan C., Nakamura, Ronan, Ciranna, Nicolás S., Sarotto, Aníbal, Dorfman, Verónica B., López-Costa, Juan J., Zapico, José M., Ramos, Ana, de Pascual-Teresa, Beatriz, Larrayoz, Ignacio M., Loidl, César F., Martínez, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899795/
https://www.ncbi.nlm.nih.gov/pubmed/36755945
http://dx.doi.org/10.3389/fphar.2023.1112318

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