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Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility

Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB defense may be impacted by diabetes-related e...

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Autores principales: Ssekamatte, Phillip, Sande, Obondo James, van Crevel, Reinout, Biraro, Irene Andia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899803/
https://www.ncbi.nlm.nih.gov/pubmed/36756113
http://dx.doi.org/10.3389/fimmu.2023.1122255
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author Ssekamatte, Phillip
Sande, Obondo James
van Crevel, Reinout
Biraro, Irene Andia
author_facet Ssekamatte, Phillip
Sande, Obondo James
van Crevel, Reinout
Biraro, Irene Andia
author_sort Ssekamatte, Phillip
collection PubMed
description Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB defense may be impacted by diabetes-related effects on immunity, metabolism, and gene transcription. An update on the epidemiological aspects of DM and TB, and the recent trends in understanding the DM-associated immunologic, metabolic, and genetic mechanisms of susceptibility to TB will be discussed in this review. This review highlights gaps in the incomplete understanding of the mechanisms that may relate to TB susceptibility in type 2 DM (T2DM). Understanding these three main domains regarding mechanisms of TB susceptibility in T2DM patients can help us build practical treatment plans to lessen the combined burden of the diseases in rampant areas.
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spelling pubmed-98998032023-02-07 Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility Ssekamatte, Phillip Sande, Obondo James van Crevel, Reinout Biraro, Irene Andia Front Immunol Immunology Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB defense may be impacted by diabetes-related effects on immunity, metabolism, and gene transcription. An update on the epidemiological aspects of DM and TB, and the recent trends in understanding the DM-associated immunologic, metabolic, and genetic mechanisms of susceptibility to TB will be discussed in this review. This review highlights gaps in the incomplete understanding of the mechanisms that may relate to TB susceptibility in type 2 DM (T2DM). Understanding these three main domains regarding mechanisms of TB susceptibility in T2DM patients can help us build practical treatment plans to lessen the combined burden of the diseases in rampant areas. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9899803/ /pubmed/36756113 http://dx.doi.org/10.3389/fimmu.2023.1122255 Text en Copyright © 2023 Ssekamatte, Sande, van Crevel and Biraro https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ssekamatte, Phillip
Sande, Obondo James
van Crevel, Reinout
Biraro, Irene Andia
Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
title Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
title_full Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
title_fullStr Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
title_full_unstemmed Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
title_short Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
title_sort immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899803/
https://www.ncbi.nlm.nih.gov/pubmed/36756113
http://dx.doi.org/10.3389/fimmu.2023.1122255
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