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Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB defense may be impacted by diabetes-related e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899803/ https://www.ncbi.nlm.nih.gov/pubmed/36756113 http://dx.doi.org/10.3389/fimmu.2023.1122255 |
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author | Ssekamatte, Phillip Sande, Obondo James van Crevel, Reinout Biraro, Irene Andia |
author_facet | Ssekamatte, Phillip Sande, Obondo James van Crevel, Reinout Biraro, Irene Andia |
author_sort | Ssekamatte, Phillip |
collection | PubMed |
description | Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB defense may be impacted by diabetes-related effects on immunity, metabolism, and gene transcription. An update on the epidemiological aspects of DM and TB, and the recent trends in understanding the DM-associated immunologic, metabolic, and genetic mechanisms of susceptibility to TB will be discussed in this review. This review highlights gaps in the incomplete understanding of the mechanisms that may relate to TB susceptibility in type 2 DM (T2DM). Understanding these three main domains regarding mechanisms of TB susceptibility in T2DM patients can help us build practical treatment plans to lessen the combined burden of the diseases in rampant areas. |
format | Online Article Text |
id | pubmed-9899803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98998032023-02-07 Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility Ssekamatte, Phillip Sande, Obondo James van Crevel, Reinout Biraro, Irene Andia Front Immunol Immunology Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB defense may be impacted by diabetes-related effects on immunity, metabolism, and gene transcription. An update on the epidemiological aspects of DM and TB, and the recent trends in understanding the DM-associated immunologic, metabolic, and genetic mechanisms of susceptibility to TB will be discussed in this review. This review highlights gaps in the incomplete understanding of the mechanisms that may relate to TB susceptibility in type 2 DM (T2DM). Understanding these three main domains regarding mechanisms of TB susceptibility in T2DM patients can help us build practical treatment plans to lessen the combined burden of the diseases in rampant areas. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9899803/ /pubmed/36756113 http://dx.doi.org/10.3389/fimmu.2023.1122255 Text en Copyright © 2023 Ssekamatte, Sande, van Crevel and Biraro https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ssekamatte, Phillip Sande, Obondo James van Crevel, Reinout Biraro, Irene Andia Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_full | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_fullStr | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_full_unstemmed | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_short | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_sort | immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899803/ https://www.ncbi.nlm.nih.gov/pubmed/36756113 http://dx.doi.org/10.3389/fimmu.2023.1122255 |
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