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Current status and future promise of next-generation poly (ADP-Ribose) polymerase 1-selective inhibitor AZD5305
The family of poly (ADP-ribose) polymerases (PARPs) consists of 17 members, which have been demonstrated as having effects on a series of cellular processes, including DNA replication and repair. PARP inhibitors (PARPi) suppress DNA repair through “PARP trapping”, thus, constitute an important treat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899804/ https://www.ncbi.nlm.nih.gov/pubmed/36756144 http://dx.doi.org/10.3389/fphar.2022.979873 |