Autophagy-dependent ferroptosis in kidney disease

Ferroptosis is a new type of cell death caused by the lack of glutathione peroxidase 4 (GPX4) and the imbalance of cellular redox. It is characterized by the accumulation of lipid peroxides on cell membranes. Multiple regulatory pathways of ferroptosis include the GPX4, glutamate-cystine antiporter...

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Autores principales: Yang, Yuanting, Cheng, Jiayi, Lin, Qisheng, Ni, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899808/
https://www.ncbi.nlm.nih.gov/pubmed/36755884
http://dx.doi.org/10.3389/fmed.2022.1071864
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author Yang, Yuanting
Cheng, Jiayi
Lin, Qisheng
Ni, Zhaohui
author_facet Yang, Yuanting
Cheng, Jiayi
Lin, Qisheng
Ni, Zhaohui
author_sort Yang, Yuanting
collection PubMed
description Ferroptosis is a new type of cell death caused by the lack of glutathione peroxidase 4 (GPX4) and the imbalance of cellular redox. It is characterized by the accumulation of lipid peroxides on cell membranes. Multiple regulatory pathways of ferroptosis include the GPX4, glutamate-cystine antiporter (System Xc(–)), lipid metabolism, and iron metabolism pathways. Recent studies have reported that autophagy-dependent ferroptosis (ferroptosis meditated by ferritinophagy, lipophagy, and clockophagy) plays a significant role in the occurrence of several diseases, including diseases affecting the nerves, liver, lungs, and kidneys. This review provides an overview of research progress made on autophagy-dependent ferroptosis in kidney diseases.
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spelling pubmed-98998082023-02-07 Autophagy-dependent ferroptosis in kidney disease Yang, Yuanting Cheng, Jiayi Lin, Qisheng Ni, Zhaohui Front Med (Lausanne) Medicine Ferroptosis is a new type of cell death caused by the lack of glutathione peroxidase 4 (GPX4) and the imbalance of cellular redox. It is characterized by the accumulation of lipid peroxides on cell membranes. Multiple regulatory pathways of ferroptosis include the GPX4, glutamate-cystine antiporter (System Xc(–)), lipid metabolism, and iron metabolism pathways. Recent studies have reported that autophagy-dependent ferroptosis (ferroptosis meditated by ferritinophagy, lipophagy, and clockophagy) plays a significant role in the occurrence of several diseases, including diseases affecting the nerves, liver, lungs, and kidneys. This review provides an overview of research progress made on autophagy-dependent ferroptosis in kidney diseases. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9899808/ /pubmed/36755884 http://dx.doi.org/10.3389/fmed.2022.1071864 Text en Copyright © 2023 Yang, Cheng, Lin and Ni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Yang, Yuanting
Cheng, Jiayi
Lin, Qisheng
Ni, Zhaohui
Autophagy-dependent ferroptosis in kidney disease
title Autophagy-dependent ferroptosis in kidney disease
title_full Autophagy-dependent ferroptosis in kidney disease
title_fullStr Autophagy-dependent ferroptosis in kidney disease
title_full_unstemmed Autophagy-dependent ferroptosis in kidney disease
title_short Autophagy-dependent ferroptosis in kidney disease
title_sort autophagy-dependent ferroptosis in kidney disease
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899808/
https://www.ncbi.nlm.nih.gov/pubmed/36755884
http://dx.doi.org/10.3389/fmed.2022.1071864
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AT chengjiayi autophagydependentferroptosisinkidneydisease
AT linqisheng autophagydependentferroptosisinkidneydisease
AT nizhaohui autophagydependentferroptosisinkidneydisease

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