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The clinical and immunological basis of early food introduction in food allergy prevention

IgE-mediated food allergy has an estimated prevalence of 6%–10% in developed countries. Allergen avoidance has long been the main focus in the prevention of food allergy and late solid food introduction after 6–12 months of age was recommended in high-risk infants. However, the rising prevalence of...

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Autores principales: Nuyttens, L., De Vlieger, L., Diels, M., Schrijvers, R., Bullens, D. M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899849/
https://www.ncbi.nlm.nih.gov/pubmed/36756279
http://dx.doi.org/10.3389/falgy.2023.1111687
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author Nuyttens, L.
De Vlieger, L.
Diels, M.
Schrijvers, R.
Bullens, D. M. A.
author_facet Nuyttens, L.
De Vlieger, L.
Diels, M.
Schrijvers, R.
Bullens, D. M. A.
author_sort Nuyttens, L.
collection PubMed
description IgE-mediated food allergy has an estimated prevalence of 6%–10% in developed countries. Allergen avoidance has long been the main focus in the prevention of food allergy and late solid food introduction after 6–12 months of age was recommended in high-risk infants. However, the rising prevalence of food allergy despite delayed exposure to allergens and the observations that IgE-mediated sensitization to food products could even occur before the introduction of solid foods resulted in a shift towards early solid food introduction as an attempt to prevent IgE-mediated food allergy. Since then, many trials focused on the clinical outcome of early allergen introduction and overall seem to point to a protective effect on the development of IgE-mediated food allergies. For non-IgE-mediated diseases of food allergy, evidence of early food introduction seems less clear. Moreover, data on the underlying immunological processes in early food introduction is lacking. The goal of this review is to summarize the available data of immunological changes in early food introduction to prevent IgE and non-IgE mediated food allergy.
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spelling pubmed-98998492023-02-07 The clinical and immunological basis of early food introduction in food allergy prevention Nuyttens, L. De Vlieger, L. Diels, M. Schrijvers, R. Bullens, D. M. A. Front Allergy Allergy IgE-mediated food allergy has an estimated prevalence of 6%–10% in developed countries. Allergen avoidance has long been the main focus in the prevention of food allergy and late solid food introduction after 6–12 months of age was recommended in high-risk infants. However, the rising prevalence of food allergy despite delayed exposure to allergens and the observations that IgE-mediated sensitization to food products could even occur before the introduction of solid foods resulted in a shift towards early solid food introduction as an attempt to prevent IgE-mediated food allergy. Since then, many trials focused on the clinical outcome of early allergen introduction and overall seem to point to a protective effect on the development of IgE-mediated food allergies. For non-IgE-mediated diseases of food allergy, evidence of early food introduction seems less clear. Moreover, data on the underlying immunological processes in early food introduction is lacking. The goal of this review is to summarize the available data of immunological changes in early food introduction to prevent IgE and non-IgE mediated food allergy. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9899849/ /pubmed/36756279 http://dx.doi.org/10.3389/falgy.2023.1111687 Text en © 2023 Nuyttens, De Vlieger, Diels, Schrijvers and Bullens. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Allergy
Nuyttens, L.
De Vlieger, L.
Diels, M.
Schrijvers, R.
Bullens, D. M. A.
The clinical and immunological basis of early food introduction in food allergy prevention
title The clinical and immunological basis of early food introduction in food allergy prevention
title_full The clinical and immunological basis of early food introduction in food allergy prevention
title_fullStr The clinical and immunological basis of early food introduction in food allergy prevention
title_full_unstemmed The clinical and immunological basis of early food introduction in food allergy prevention
title_short The clinical and immunological basis of early food introduction in food allergy prevention
title_sort clinical and immunological basis of early food introduction in food allergy prevention
topic Allergy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899849/
https://www.ncbi.nlm.nih.gov/pubmed/36756279
http://dx.doi.org/10.3389/falgy.2023.1111687
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