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Elucidating the molecular determinants in the process of gastrin C-terminal pentapeptide amide end activating cholecystokinin 2 receptor by Gaussian accelerated molecular dynamics simulations

Gastrin plays important role in stimulating the initiation and development of many gastrointestinal diseases through interacting with the cholecystokinin 2 receptor (CCK2R). The smallest bioactive unit of gastrin activating CCK2R is the C-terminal tetrapeptide capped with an indispensable amide end....

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Detalles Bibliográficos
Autores principales:	Yang, Kecheng, Jin, Huiyuan, Gao, Xu, Wang, Gang-Cheng, Zhang, Guo-Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899899/ https://www.ncbi.nlm.nih.gov/pubmed/36756145 http://dx.doi.org/10.3389/fphar.2022.1054575

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