The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials

Tripartite motif-containing 28 (TRIM28) belongs to tripartite motif (TRIM) family. TRIM28 not only binds and degrades its downstream target, but also acts as a transcription co-factor to inhibit gene expression. More and more studies have shown that TRIM28 plays a vital role in tumor genesis and pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yiqing, Tan, Shiming, Han, Yaqian, Huang, Lisheng, Yang, Ruiqian, Hu, Zifan, Tao, Yi, Oyang, Linda, Lin, Jinguan, Peng, Qiu, Jiang, Xianjie, Xu, Xuemeng, Xia, Longzheng, Peng, Mingjing, Wu, Nayiyuan, Tang, Yanyan, Li, Xiaoling, Liao, Qianjin, Zhou, Yujuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899900/
https://www.ncbi.nlm.nih.gov/pubmed/36756159
http://dx.doi.org/10.3389/fonc.2023.1100134
_version_ 1784882733490634752
author Yang, Yiqing
Tan, Shiming
Han, Yaqian
Huang, Lisheng
Yang, Ruiqian
Hu, Zifan
Tao, Yi
Oyang, Linda
Lin, Jinguan
Peng, Qiu
Jiang, Xianjie
Xu, Xuemeng
Xia, Longzheng
Peng, Mingjing
Wu, Nayiyuan
Tang, Yanyan
Li, Xiaoling
Liao, Qianjin
Zhou, Yujuan
author_facet Yang, Yiqing
Tan, Shiming
Han, Yaqian
Huang, Lisheng
Yang, Ruiqian
Hu, Zifan
Tao, Yi
Oyang, Linda
Lin, Jinguan
Peng, Qiu
Jiang, Xianjie
Xu, Xuemeng
Xia, Longzheng
Peng, Mingjing
Wu, Nayiyuan
Tang, Yanyan
Li, Xiaoling
Liao, Qianjin
Zhou, Yujuan
author_sort Yang, Yiqing
collection PubMed
description Tripartite motif-containing 28 (TRIM28) belongs to tripartite motif (TRIM) family. TRIM28 not only binds and degrades its downstream target, but also acts as a transcription co-factor to inhibit gene expression. More and more studies have shown that TRIM28 plays a vital role in tumor genesis and progression. Here, we reviewed the role of TRIM28 in tumor proliferation, migration, invasion and cell death. Moreover, we also summarized the important role of TRIM28 in tumor stemness sustainability and immune regulation. Because of the importance of TRIM28 in tumors, TIRM28 may be a candidate target for anti-tumor therapy and play an important role in tumor diagnosis and treatment in the future.
format Online
Article
Text
id pubmed-9899900
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98999002023-02-07 The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials Yang, Yiqing Tan, Shiming Han, Yaqian Huang, Lisheng Yang, Ruiqian Hu, Zifan Tao, Yi Oyang, Linda Lin, Jinguan Peng, Qiu Jiang, Xianjie Xu, Xuemeng Xia, Longzheng Peng, Mingjing Wu, Nayiyuan Tang, Yanyan Li, Xiaoling Liao, Qianjin Zhou, Yujuan Front Oncol Oncology Tripartite motif-containing 28 (TRIM28) belongs to tripartite motif (TRIM) family. TRIM28 not only binds and degrades its downstream target, but also acts as a transcription co-factor to inhibit gene expression. More and more studies have shown that TRIM28 plays a vital role in tumor genesis and progression. Here, we reviewed the role of TRIM28 in tumor proliferation, migration, invasion and cell death. Moreover, we also summarized the important role of TRIM28 in tumor stemness sustainability and immune regulation. Because of the importance of TRIM28 in tumors, TIRM28 may be a candidate target for anti-tumor therapy and play an important role in tumor diagnosis and treatment in the future. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9899900/ /pubmed/36756159 http://dx.doi.org/10.3389/fonc.2023.1100134 Text en Copyright © 2023 Yang, Tan, Han, Huang, Yang, Hu, Tao, Oyang, Lin, Peng, Jiang, Xu, Xia, Peng, Wu, Tang, Li, Liao and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yang, Yiqing
Tan, Shiming
Han, Yaqian
Huang, Lisheng
Yang, Ruiqian
Hu, Zifan
Tao, Yi
Oyang, Linda
Lin, Jinguan
Peng, Qiu
Jiang, Xianjie
Xu, Xuemeng
Xia, Longzheng
Peng, Mingjing
Wu, Nayiyuan
Tang, Yanyan
Li, Xiaoling
Liao, Qianjin
Zhou, Yujuan
The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
title The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
title_full The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
title_fullStr The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
title_full_unstemmed The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
title_short The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
title_sort role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899900/
https://www.ncbi.nlm.nih.gov/pubmed/36756159
http://dx.doi.org/10.3389/fonc.2023.1100134
work_keys_str_mv AT yangyiqing theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT tanshiming theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT hanyaqian theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT huanglisheng theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT yangruiqian theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT huzifan theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT taoyi theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT oyanglinda theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT linjinguan theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT pengqiu theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT jiangxianjie theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT xuxuemeng theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT xialongzheng theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT pengmingjing theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT wunayiyuan theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT tangyanyan theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT lixiaoling theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT liaoqianjin theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT zhouyujuan theroleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT yangyiqing roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT tanshiming roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT hanyaqian roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT huanglisheng roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT yangruiqian roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT huzifan roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT taoyi roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT oyanglinda roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT linjinguan roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT pengqiu roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT jiangxianjie roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT xuxuemeng roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT xialongzheng roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT pengmingjing roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT wunayiyuan roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT tangyanyan roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT lixiaoling roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT liaoqianjin roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials
AT zhouyujuan roleoftripartitemotifcontaining28incancerprogressionanditstherapeuticpotentials

Ejemplares similares