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Epidemiology and survival of patients with central nervous system solitary fibrous tumors: A population-based analysis
BACKGROUND: The objective of this study was to determine population-based estimates of the epidemiology and prognosis of central nervous system solitary fibrous tumors (cSFTs). METHODS: We extracted the data of patients diagnosed with cSFTs between 2004 and 2018 from the Surveillance, Epidemiology,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899901/ https://www.ncbi.nlm.nih.gov/pubmed/36755855 http://dx.doi.org/10.3389/fonc.2022.977629 |
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author | Lu, Taikun Xu, Haiyang Dong, Xuechao Jin, Zheng Wang, Yubo |
author_facet | Lu, Taikun Xu, Haiyang Dong, Xuechao Jin, Zheng Wang, Yubo |
author_sort | Lu, Taikun |
collection | PubMed |
description | BACKGROUND: The objective of this study was to determine population-based estimates of the epidemiology and prognosis of central nervous system solitary fibrous tumors (cSFTs). METHODS: We extracted the data of patients diagnosed with cSFTs between 2004 and 2018 from the Surveillance, Epidemiology, and End Results database. We analyzed the distribution of patients according to their demographic and clinical characteristics. Binary logistic regression analysis was performed to predict which patients would be diagnosed with malignant cSFT. Possible prognostic indicators were analyzed by multivariable Cox proportional hazards models. RESULTS: A total of 650 cases were included. The majority of patients were diagnosed at 50-59 years old, and the median age at diagnosis was 55 years. A total of 13.4% of the tumors were located in the spinal canal, and 24% of the tumors were benign. Most of the tumors were larger than 3 cm, but distant metastasis was rare. Tumor resection was the first choice of treatment for these patients, and total resection was achieved in 51.1%. Radiation therapy after surgery was also administered to 42.3% of the patients. The median survival was 57 months. Intracranial tumors and tumors with distant metastasis tended to be malignant. The results of the log-rank test showed that the patients who underwent total resection had better overall survival (OS), but the effect of radiation therapy after surgery was not significant. CONCLUSION: cSFT is a rare and aggressive type of tumor. Tumor resection is the first choice for treatment, and radiation therapy after surgery does not improve OS. Patients older than 60 years of age who are diagnosed with intracranial tumors, malignant tumors and distant metastasis have worse OS outcomes than their counterparts. |
format | Online Article Text |
id | pubmed-9899901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98999012023-02-07 Epidemiology and survival of patients with central nervous system solitary fibrous tumors: A population-based analysis Lu, Taikun Xu, Haiyang Dong, Xuechao Jin, Zheng Wang, Yubo Front Oncol Oncology BACKGROUND: The objective of this study was to determine population-based estimates of the epidemiology and prognosis of central nervous system solitary fibrous tumors (cSFTs). METHODS: We extracted the data of patients diagnosed with cSFTs between 2004 and 2018 from the Surveillance, Epidemiology, and End Results database. We analyzed the distribution of patients according to their demographic and clinical characteristics. Binary logistic regression analysis was performed to predict which patients would be diagnosed with malignant cSFT. Possible prognostic indicators were analyzed by multivariable Cox proportional hazards models. RESULTS: A total of 650 cases were included. The majority of patients were diagnosed at 50-59 years old, and the median age at diagnosis was 55 years. A total of 13.4% of the tumors were located in the spinal canal, and 24% of the tumors were benign. Most of the tumors were larger than 3 cm, but distant metastasis was rare. Tumor resection was the first choice of treatment for these patients, and total resection was achieved in 51.1%. Radiation therapy after surgery was also administered to 42.3% of the patients. The median survival was 57 months. Intracranial tumors and tumors with distant metastasis tended to be malignant. The results of the log-rank test showed that the patients who underwent total resection had better overall survival (OS), but the effect of radiation therapy after surgery was not significant. CONCLUSION: cSFT is a rare and aggressive type of tumor. Tumor resection is the first choice for treatment, and radiation therapy after surgery does not improve OS. Patients older than 60 years of age who are diagnosed with intracranial tumors, malignant tumors and distant metastasis have worse OS outcomes than their counterparts. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9899901/ /pubmed/36755855 http://dx.doi.org/10.3389/fonc.2022.977629 Text en Copyright © 2023 Lu, Xu, Dong, Jin and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Lu, Taikun Xu, Haiyang Dong, Xuechao Jin, Zheng Wang, Yubo Epidemiology and survival of patients with central nervous system solitary fibrous tumors: A population-based analysis |
title | Epidemiology and survival of patients with central nervous system solitary fibrous tumors: A population-based analysis |
title_full | Epidemiology and survival of patients with central nervous system solitary fibrous tumors: A population-based analysis |
title_fullStr | Epidemiology and survival of patients with central nervous system solitary fibrous tumors: A population-based analysis |
title_full_unstemmed | Epidemiology and survival of patients with central nervous system solitary fibrous tumors: A population-based analysis |
title_short | Epidemiology and survival of patients with central nervous system solitary fibrous tumors: A population-based analysis |
title_sort | epidemiology and survival of patients with central nervous system solitary fibrous tumors: a population-based analysis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899901/ https://www.ncbi.nlm.nih.gov/pubmed/36755855 http://dx.doi.org/10.3389/fonc.2022.977629 |
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