Obesity and endocrine-related cancer: The important role of IGF-1

Obesity is increasingly becoming a global epidemic of concern and is considered a risk factor for several endocrine-related cancers. Moreover, obesity is associated with cancer development and poor prognosis. As a metabolic abnormality, obesity leads to a series of changes in insulin, IGF-1, sex hor...

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Autores principales: Zhong, Wentao, Wang, Xueqing, Wang, Yufei, Sun, Guoqian, Zhang, Jia, Li, Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899991/
https://www.ncbi.nlm.nih.gov/pubmed/36755926
http://dx.doi.org/10.3389/fendo.2023.1093257
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author Zhong, Wentao
Wang, Xueqing
Wang, Yufei
Sun, Guoqian
Zhang, Jia
Li, Zhuo
author_facet Zhong, Wentao
Wang, Xueqing
Wang, Yufei
Sun, Guoqian
Zhang, Jia
Li, Zhuo
author_sort Zhong, Wentao
collection PubMed
description Obesity is increasingly becoming a global epidemic of concern and is considered a risk factor for several endocrine-related cancers. Moreover, obesity is associated with cancer development and poor prognosis. As a metabolic abnormality, obesity leads to a series of changes in insulin, IGF-1, sex hormones, IGFBPs, and adipokines. Among these factors, IGF-1 plays an important role in obesity-related endocrine cancers. This review describes the role of obesity in endocrine-related cancers, such as prostate cancer, breast cancer and pancreatic cancer, focusing on the mechanism of IGF-1 and the crosstalk with estrogen and adipokines. In addition, this review briefly introduces the current status of IGF-1R inhibitors in clinical practice and shows the prospect of IGF-1R inhibitors in combination with other anticancer drugs.
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spelling pubmed-98999912023-02-07 Obesity and endocrine-related cancer: The important role of IGF-1 Zhong, Wentao Wang, Xueqing Wang, Yufei Sun, Guoqian Zhang, Jia Li, Zhuo Front Endocrinol (Lausanne) Endocrinology Obesity is increasingly becoming a global epidemic of concern and is considered a risk factor for several endocrine-related cancers. Moreover, obesity is associated with cancer development and poor prognosis. As a metabolic abnormality, obesity leads to a series of changes in insulin, IGF-1, sex hormones, IGFBPs, and adipokines. Among these factors, IGF-1 plays an important role in obesity-related endocrine cancers. This review describes the role of obesity in endocrine-related cancers, such as prostate cancer, breast cancer and pancreatic cancer, focusing on the mechanism of IGF-1 and the crosstalk with estrogen and adipokines. In addition, this review briefly introduces the current status of IGF-1R inhibitors in clinical practice and shows the prospect of IGF-1R inhibitors in combination with other anticancer drugs. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9899991/ /pubmed/36755926 http://dx.doi.org/10.3389/fendo.2023.1093257 Text en Copyright © 2023 Zhong, Wang, Wang, Sun, Zhang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhong, Wentao
Wang, Xueqing
Wang, Yufei
Sun, Guoqian
Zhang, Jia
Li, Zhuo
Obesity and endocrine-related cancer: The important role of IGF-1
title Obesity and endocrine-related cancer: The important role of IGF-1
title_full Obesity and endocrine-related cancer: The important role of IGF-1
title_fullStr Obesity and endocrine-related cancer: The important role of IGF-1
title_full_unstemmed Obesity and endocrine-related cancer: The important role of IGF-1
title_short Obesity and endocrine-related cancer: The important role of IGF-1
title_sort obesity and endocrine-related cancer: the important role of igf-1
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899991/
https://www.ncbi.nlm.nih.gov/pubmed/36755926
http://dx.doi.org/10.3389/fendo.2023.1093257
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