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Anticancer effects of licochalcones: A review of the mechanisms

Cancer is a disease with a high fatality rate representing a serious threat to human health. Researchers have tried to identify effective anticancer drugs. Licorice is a widely used traditional Chinese medicine with various pharmacological properties, and licorice-derived flavonoids include licochal...

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Autores principales: Deng, Nan, Qiao, Mingming, Li, Ying, Liang, Fengyan, Li, Jingjing, Liu, Yanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900005/
https://www.ncbi.nlm.nih.gov/pubmed/36755942
http://dx.doi.org/10.3389/fphar.2023.1074506
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author Deng, Nan
Qiao, Mingming
Li, Ying
Liang, Fengyan
Li, Jingjing
Liu, Yanfeng
author_facet Deng, Nan
Qiao, Mingming
Li, Ying
Liang, Fengyan
Li, Jingjing
Liu, Yanfeng
author_sort Deng, Nan
collection PubMed
description Cancer is a disease with a high fatality rate representing a serious threat to human health. Researchers have tried to identify effective anticancer drugs. Licorice is a widely used traditional Chinese medicine with various pharmacological properties, and licorice-derived flavonoids include licochalcones like licochalcone A, licochalcone B, licochalcone C, licochalcone D, licochalcone E, and licochalcone H. By regulating the expression in multiple signaling pathways such as the EGFR/ERK, PI3K/Akt/mTOR, p38/JNK, JAK2/STAT3, MEK/ERK, Wnt/β-catenin, and MKK4/JNK pathways, and their downstream proteins, licochalcones can activate the mitochondrial apoptosis pathway and death receptor pathway, promote autophagy-related protein expression, inhibit the expression of cell cycle proteins and angiogenesis factors, regulate autophagy and apoptosis, and inhibit the proliferation, migration, and invasion of cancer cells. Among the licochalcones, the largest number of studies examined licochalcone A, far more than other licochalcones. Licochalcone A not only has prominent anticancer effects but also can be used to inhibit the efflux of antineoplastic drugs from cancer cells. Moreover, derivatives of licochalcone A exhibit strong antitumor effects. Currently, most results of the anticancer effects of licochalcones are derived from cell experiments. Thus, more clinical studies are needed to confirm the antineoplastic effects of licochalcones.
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spelling pubmed-99000052023-02-07 Anticancer effects of licochalcones: A review of the mechanisms Deng, Nan Qiao, Mingming Li, Ying Liang, Fengyan Li, Jingjing Liu, Yanfeng Front Pharmacol Pharmacology Cancer is a disease with a high fatality rate representing a serious threat to human health. Researchers have tried to identify effective anticancer drugs. Licorice is a widely used traditional Chinese medicine with various pharmacological properties, and licorice-derived flavonoids include licochalcones like licochalcone A, licochalcone B, licochalcone C, licochalcone D, licochalcone E, and licochalcone H. By regulating the expression in multiple signaling pathways such as the EGFR/ERK, PI3K/Akt/mTOR, p38/JNK, JAK2/STAT3, MEK/ERK, Wnt/β-catenin, and MKK4/JNK pathways, and their downstream proteins, licochalcones can activate the mitochondrial apoptosis pathway and death receptor pathway, promote autophagy-related protein expression, inhibit the expression of cell cycle proteins and angiogenesis factors, regulate autophagy and apoptosis, and inhibit the proliferation, migration, and invasion of cancer cells. Among the licochalcones, the largest number of studies examined licochalcone A, far more than other licochalcones. Licochalcone A not only has prominent anticancer effects but also can be used to inhibit the efflux of antineoplastic drugs from cancer cells. Moreover, derivatives of licochalcone A exhibit strong antitumor effects. Currently, most results of the anticancer effects of licochalcones are derived from cell experiments. Thus, more clinical studies are needed to confirm the antineoplastic effects of licochalcones. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9900005/ /pubmed/36755942 http://dx.doi.org/10.3389/fphar.2023.1074506 Text en Copyright © 2023 Deng, Qiao, Li, Liang, Li and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Deng, Nan
Qiao, Mingming
Li, Ying
Liang, Fengyan
Li, Jingjing
Liu, Yanfeng
Anticancer effects of licochalcones: A review of the mechanisms
title Anticancer effects of licochalcones: A review of the mechanisms
title_full Anticancer effects of licochalcones: A review of the mechanisms
title_fullStr Anticancer effects of licochalcones: A review of the mechanisms
title_full_unstemmed Anticancer effects of licochalcones: A review of the mechanisms
title_short Anticancer effects of licochalcones: A review of the mechanisms
title_sort anticancer effects of licochalcones: a review of the mechanisms
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900005/
https://www.ncbi.nlm.nih.gov/pubmed/36755942
http://dx.doi.org/10.3389/fphar.2023.1074506
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