Homocysteine-induced endoplasmic reticulum stress activates FGF21 and is associated with browning and atrophy of white adipose tissue in Bhmt knockout mice

Betaine-homocysteine methyltransferase (BHMT) catalyzes the transfer of methyl groups from betaine to homocysteine (Hcy), producing methionine and dimethylglycine. In this work, we characterize Bhmt wild type (Bhmt-WT) and knockout (Bhmt-KO) mice that were fully backcrossed to a C57Bl6/J background....

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Detalles Bibliográficos
Autores principales: Warrier, Manya, Paules, Evan M., Silva-Gomez, Jorge, Friday, Walter B., Bramlett, Frances, Kim, Hyunbae, Zhang, Kezhong, Trujillo-Gonzalez, Isis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900266/
https://www.ncbi.nlm.nih.gov/pubmed/36755585
http://dx.doi.org/10.1016/j.heliyon.2023.e13216

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