Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies

A lack of models that recapitulate the complexity of human bone marrow has hampered mechanistic studies of normal and malignant hematopoiesis and the validation of novel therapies. Here, we describe a step-wise, directed-differentiation protocol in which organoids are generated from induced pluripot...

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Detalles Bibliográficos
Autores principales: Khan, Abdullah O., Rodriguez-Romera, Antonio, Reyat, Jasmeet S., Olijnik, Aude-Anais, Colombo, Michela, Wang, Guanlin, Wen, Wei Xiong, Sousos, Nikolaos, Murphy, Lauren C., Grygielska, Beata, Perrella, Gina, Mahony, Christopher B., Ling, Rebecca E., Elliott, Natalina E., Karali, Christina Simoglou, Stone, Andrew P., Kemble, Samuel, Cutler, Emily A., Fielding, Adele K., Croft, Adam P., Bassett, David, Poologasundarampillai, Gowsihan, Roy, Anindita, Gooding, Sarah, Rayes, Julie, Machlus, Kellie R., Psaila, Bethan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900323/
https://www.ncbi.nlm.nih.gov/pubmed/36351055
http://dx.doi.org/10.1158/2159-8290.CD-22-0199

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