Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability

Isocitrate dehydrogenase 1 and 2 (IDH) are mutated in multiple cancers and drive production of (R)-2-hydroxyglutarate (2HG). We identified a lipid synthesis enzyme [acetyl CoA carboxylase 1 (ACC1)] as a synthetic lethal target in mutant IDH1 (mIDH1), but not mIDH2, cancers. Here, we analyzed the met...

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Detalles Bibliográficos
Autores principales: Thomas, Daniel, Wu, Manhong, Nakauchi, Yusuke, Zheng, Ming, Thompson-Peach, Chloe A.L., Lim, Kelly, Landberg, Niklas, Köhnke, Thomas, Robinson, Nirmal, Kaur, Satinder, Kutyna, Monika, Stafford, Melissa, Hiwase, Devendra, Reinisch, Andreas, Peltz, Gary, Majeti, Ravindra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900324/
https://www.ncbi.nlm.nih.gov/pubmed/36355448
http://dx.doi.org/10.1158/2159-8290.CD-21-0218

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