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Hyperphosphorylation of hepatic proteome characterizes nonalcoholic fatty liver disease in S-adenosylmethionine deficiency

Methionine adenosyltransferase 1a (MAT1A) is responsible for hepatic S-adenosyl-L-methionine (SAMe) biosynthesis. Mat1a(−/−) mice have hepatic SAMe depletion, develop nonalcoholic steatohepatitis (NASH) which is reversed with SAMe administration. We examined temporal alterations in the proteome/phos...

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Detalles Bibliográficos
Autores principales:	Robinson, Aaron E., Binek, Aleksandra, Ramani, Komal, Sundararaman, Niveda, Barbier-Torres, Lucía, Murray, Ben, Venkatraman, Vidya, Kreimer, Simion, Ardle, Angela Mc, Noureddin, Mazen, Fernández-Ramos, David, Lopitz-Otsoa, Fernando, Gutiérrez de Juan, Virginia, Millet, Oscar, Mato, José M., Lu, Shelly C., Van Eyk, Jennifer E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900401/ https://www.ncbi.nlm.nih.gov/pubmed/36756374 http://dx.doi.org/10.1016/j.isci.2023.105987

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