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Ku–DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks

The DNA-dependent protein kinase (DNA-PK) plays a critical role in the DNA damage response (DDR) and non-homologous end joining (NHEJ) double-strand break (DSB) repair pathways. Consequently, DNA-PK is a validated therapeutic target for cancer treatment in certain DNA repair-deficient cancers and in...

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Detalles Bibliográficos
Autores principales:	Mendoza-Munoz, Pamela L, Gavande, Navnath S, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Dynlacht, Joseph R, Garrett, Joy E, Turchi, John J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900423/ https://www.ncbi.nlm.nih.gov/pubmed/36755959 http://dx.doi.org/10.1093/narcan/zcad003

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