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Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy

DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The ‘Y-family’ trans-lesion synthesis (TLS) DNA polymerases enable cells to replicate damaged genomes, thereby conferring DNA damage...

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Detalles Bibliográficos
Autores principales:	Anand, Jay, Chiou, Lilly, Sciandra, Carly, Zhang, Xingyuan, Hong, Jiyong, Wu, Di, Zhou, Pei, Vaziri, Cyrus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Critical Reviews and Perspectives
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900426/ https://www.ncbi.nlm.nih.gov/pubmed/36755961 http://dx.doi.org/10.1093/narcan/zcad005

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