Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation

Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma that includes fusion-positive (FP) and fusion-negative (FN) molecular subtypes. FP-RMS expresses PAX3-FOXO1 fusion protein and often shows dismal prognosis. FN-RMS shows cytogenetic abnormalities and frequently harbors RAS pathway mu...

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Detalles Bibliográficos
Autores principales: Perrone, Clara, Pomella, Silvia, Cassandri, Matteo, Pezzella, Michele, Giuliani, Stefano, Gasperi, Tecla, Porrazzo, Antonella, Alisi, Anna, Pastore, Anna, Codenotti, Silvia, Fanzani, Alessandro, Barillari, Giovanni, Conti, Libenzio Adrian, De Angelis, Biagio, Quintarelli, Concetta, Mariottini, Paolo, Locatelli, Franco, Marampon, Francesco, Rota, Rossella, Cervelli, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900442/
https://www.ncbi.nlm.nih.gov/pubmed/36755974
http://dx.doi.org/10.3389/fcell.2023.1061570

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