Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis

Complement component 5 (C5), an important molecule in the complement cascade, blockade by antibodies shows clinical efficacy in treating complement-mediated disorders. However, insufficient blockading induced by single-nucleotide polymorphisms in the C5 protein or frequent development of “breakthrou...

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Detalles Bibliográficos
Autores principales: Kuboi, Yoshikazu, Suzuki, Yuta, Motoi, Sotaro, Matsui, Chiyuki, Toritsuka, Naoki, Nakatani, Tomoya, Tahara, Kazuhiro, Takahashi, Yoshinori, Ida, Yoko, Tomimatsu, Ayaka, Soejima, Motohiro, Imai, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900455/
https://www.ncbi.nlm.nih.gov/pubmed/36789273
http://dx.doi.org/10.1016/j.omtn.2023.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900455/
https://www.ncbi.nlm.nih.gov/pubmed/36789273
http://dx.doi.org/10.1016/j.omtn.2023.01.005

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