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PACAP-PAC1 receptor inhibition is effective in opioid induced hyperalgesia and medication overuse headache models

Opioids prescribed for pain and migraine can produce opioid-induced hyperalgesia (OIH) or medication overuse headache (MOH). We previously demonstrated that pituitary adenylate cyclase activating polypeptide (PACAP) is upregulated in OIH and chronic migraine models. Here we determined if PACAP acts...

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Detalles Bibliográficos
Autores principales:	Bertels, Zachariah, Mangutov, Elizaveta, Siegersma, Kendra, Cropper, Haley C., Tipton, Alycia, Pradhan, Amynah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900514/ https://www.ncbi.nlm.nih.gov/pubmed/36756376 http://dx.doi.org/10.1016/j.isci.2023.105950

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