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Age and the eGFR-dependent risk for adverse clinical outcomes
Although the relative risk of kidney failure increases with more severe chronic kidney disease (CKD) independent of age, with older age the absolute risk of kidney failure at a given time horizon becomes smaller. In this article, we first review some epidemiological measures of outcome occurrence (a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900576/ https://www.ncbi.nlm.nih.gov/pubmed/36755849 http://dx.doi.org/10.1093/ckj/sfac213 |
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author | Liu, Ping Ravani, Pietro |
author_facet | Liu, Ping Ravani, Pietro |
author_sort | Liu, Ping |
collection | PubMed |
description | Although the relative risk of kidney failure increases with more severe chronic kidney disease (CKD) independent of age, with older age the absolute risk of kidney failure at a given time horizon becomes smaller. In this article, we first review some epidemiological measures of outcome occurrence (absolute rate or risk) and association (relative measures: difference or ratio of rates or risks). We emphasize that relative measures need to be presented along with absolute measures to be understood and absolute risk is more helpful than absolute rate when making treatment decisions. We then apply these principles to the discussion of the absolute and relative rates or risks of kidney failure and death across categories of estimated glomerular filtration rate and age. Lastly, we discuss the implications of existing studies on whether the definition of CKD should account for age. |
format | Online Article Text |
id | pubmed-9900576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99005762023-02-07 Age and the eGFR-dependent risk for adverse clinical outcomes Liu, Ping Ravani, Pietro Clin Kidney J CKJ Review Although the relative risk of kidney failure increases with more severe chronic kidney disease (CKD) independent of age, with older age the absolute risk of kidney failure at a given time horizon becomes smaller. In this article, we first review some epidemiological measures of outcome occurrence (absolute rate or risk) and association (relative measures: difference or ratio of rates or risks). We emphasize that relative measures need to be presented along with absolute measures to be understood and absolute risk is more helpful than absolute rate when making treatment decisions. We then apply these principles to the discussion of the absolute and relative rates or risks of kidney failure and death across categories of estimated glomerular filtration rate and age. Lastly, we discuss the implications of existing studies on whether the definition of CKD should account for age. Oxford University Press 2022-09-17 /pmc/articles/PMC9900576/ /pubmed/36755849 http://dx.doi.org/10.1093/ckj/sfac213 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | CKJ Review Liu, Ping Ravani, Pietro Age and the eGFR-dependent risk for adverse clinical outcomes |
title | Age and the eGFR-dependent risk for adverse clinical outcomes |
title_full | Age and the eGFR-dependent risk for adverse clinical outcomes |
title_fullStr | Age and the eGFR-dependent risk for adverse clinical outcomes |
title_full_unstemmed | Age and the eGFR-dependent risk for adverse clinical outcomes |
title_short | Age and the eGFR-dependent risk for adverse clinical outcomes |
title_sort | age and the egfr-dependent risk for adverse clinical outcomes |
topic | CKJ Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900576/ https://www.ncbi.nlm.nih.gov/pubmed/36755849 http://dx.doi.org/10.1093/ckj/sfac213 |
work_keys_str_mv | AT liuping ageandtheegfrdependentriskforadverseclinicaloutcomes AT ravanipietro ageandtheegfrdependentriskforadverseclinicaloutcomes |