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5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity

The flavoprotein methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of N5, N10-methylenetetrahydrofolate (CH(2)-H(4)folate) to N5-methyltetrahydrofolate (CH(3)-H(4)folate), committing a methyl group from the folate cycle to the methionine one. This committed step is the sum of multi...

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Detalles Bibliográficos
Autores principales:	Yamada, Kazuhiro, Mendoza, Johnny, Koutmos, Markos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900621/ https://www.ncbi.nlm.nih.gov/pubmed/36592927 http://dx.doi.org/10.1016/j.jbc.2022.102855

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