Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory and is neuroprotective in non-rodents

The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a central regulator of learning and memory, which poses a problem for targeting it therapeutically. Indeed, our study supports prior conclusions that long-term interference with CaMKII signaling can erase pre-formed memories. By contrast,...

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Detalles Bibliográficos
Autores principales: Rumian, Nicole L., Brown, Carolyn Nicole, Hendry-Hofer, Tara B., Rossetti, Thomas, Orfila, James E., Tullis, Jonathan E., Dwoskin, Linda P., Buonarati, Olivia R., Lisman, John E., Quillinan, Nidia, Herson, Paco S., Bebarta, Vikhyat S., Bayer, K. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900743/
https://www.ncbi.nlm.nih.gov/pubmed/36747773
http://dx.doi.org/10.1101/2023.01.23.523316

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