Low frequency optogenetic deep brain stimulation of nucleus accumbens dopamine D1 or D2 receptor-containing neurons attenuates cocaine seeking selectively in male rats in part by reversing synaptic plasticity deficits

BACKGROUND: Clinically, deep brain stimulation (DBS) utilizes relatively high frequencies (>100 Hz). In preclinical models, 160 Hz stimulation of the nucleus accumbens in rodents prevents relapse of drug seeking. However, the ability of varied frequencies of accumbens DBS to attenuate drug seekin...

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Detalles Bibliográficos
Autores principales: Swinford-Jackson, Sarah E., Rich, Matthew T., Huffman, Phillip J., Knouse, Melissa C., Thomas, Arthur S., Mankame, Sharvari, Worobey, Samantha J., Pierce, R. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900748/
https://www.ncbi.nlm.nih.gov/pubmed/36747662
http://dx.doi.org/10.1101/2023.01.23.524956

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