Telomerase reactivation induces progression of mouse Braf(V600E)-driven thyroid cancers without telomere lengthening

Mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the paradigm of a cross-cancer alteration in a non-coding region. TERT promoter mutations (TPMs) are biomarkers of poor prognosis in several tumors, including thyroid cancers. TPMs enhance TERT transcription, which is...

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Detalles Bibliográficos
Autores principales: Landa, Iñigo, Thornton, Caitlin EM, Xu, Bin, Haase, Jacob, Krishnamoorthy, Gnana P., Hao, Jingzhu, Knauf, Jeffrey A, Herbert, Zachary T, Blasco, María A, Ghossein, Ronald, Fagin, James A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900760/
https://www.ncbi.nlm.nih.gov/pubmed/36747657
http://dx.doi.org/10.1101/2023.01.24.525280

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