Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

Functional loss of TDP-43, an RNA-binding protein genetically and pathologically linked to ALS and FTD, leads to inclusion of cryptic exons in hundreds of transcripts during disease. Cryptic exons can promote degradation of affected transcripts, deleteriously altering cellular function through loss-...

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Detalles Bibliográficos
Autores principales: Seddighi, Sahba, Qi, Yue A., Brown, Anna-Leigh, Wilkins, Oscar G., Bereda, Colleen, Belair, Cedric, Zhang, Yongjie, Prudencio, Mercedes, Keuss, Matthew J, Khandeshi, Aditya, Pickles, Sarah, Hill, Sarah E., Hawrot, James, Ramos, Daniel M., Yuan, Hebao, Roberts, Jessica, Kelmer Sacramento, Erika, Shah, Syed I., Nalls, Mike A., Colon-Mercado, Jenn, Reyes, Joel F., Ryan, Veronica H., Nelson, Matthew P., Cook, Casey, Li, Ziyi, Screven, Laurel, Kwan, Justin Y, Shantaraman, Anantharaman, Ping, Lingyan, Koike, Yuka, Oskarsson, Björn, Staff, Nathan, Duong, Duc M., Ahmed, Aisha, Secrier, Maria, Ule, Jerneg, Jacobson, Steven, Rohrer, Jonathan, Malaspina, Andrea, Glass, Jonathan D., Ori, Alessandro, Seyfried, Nicholas T., Maragkakis, Manolis, Petrucelli, Leonard, Fratta, Pietro, Ward, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900763/
https://www.ncbi.nlm.nih.gov/pubmed/36747793
http://dx.doi.org/10.1101/2023.01.23.525149

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