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CELL INSTANCE SEGMENTATION VIA MULTI-SCALE NON-LOCAL CORRELATION

For cell instance segmentation on Electron Microscopy (EM) images, state-of-the-art methods either conduct pixel-wise classification or follow a detection and segmentation manner. However, both approaches suffer from the enormous cell instances of EM images where cells are tightly close to each othe...

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Detalles Bibliográficos
Autores principales: Duan, Bin, Cao, Jianfeng, Wang, Wei, Cai, Dawen, Yan, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900774/
https://www.ncbi.nlm.nih.gov/pubmed/36747649
http://dx.doi.org/10.1101/2023.01.24.525387
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author Duan, Bin
Cao, Jianfeng
Wang, Wei
Cai, Dawen
Yan, Yan
author_facet Duan, Bin
Cao, Jianfeng
Wang, Wei
Cai, Dawen
Yan, Yan
author_sort Duan, Bin
collection PubMed
description For cell instance segmentation on Electron Microscopy (EM) images, state-of-the-art methods either conduct pixel-wise classification or follow a detection and segmentation manner. However, both approaches suffer from the enormous cell instances of EM images where cells are tightly close to each other and show inconsistent morphological properties and/or homogeneous appearances. This fact can easily lead to over-segmentation and under-segmentation problems for model prediction, i.e., falsely splitting and merging adjacent instances. In this paper, we propose a novel approach incorporating non-local correlation in the embedding space to make pixel features distinct or similar to their neighbors and thus address the over- and under-segmentation problems. We perform experiments on five different EM datasets where our proposed method yields better results than several strong baselines. More importantly, by using non-local correlation, we observe fewer false separations within one cell and fewer false fusions between cells.
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spelling pubmed-99007742023-02-07 CELL INSTANCE SEGMENTATION VIA MULTI-SCALE NON-LOCAL CORRELATION Duan, Bin Cao, Jianfeng Wang, Wei Cai, Dawen Yan, Yan bioRxiv Article For cell instance segmentation on Electron Microscopy (EM) images, state-of-the-art methods either conduct pixel-wise classification or follow a detection and segmentation manner. However, both approaches suffer from the enormous cell instances of EM images where cells are tightly close to each other and show inconsistent morphological properties and/or homogeneous appearances. This fact can easily lead to over-segmentation and under-segmentation problems for model prediction, i.e., falsely splitting and merging adjacent instances. In this paper, we propose a novel approach incorporating non-local correlation in the embedding space to make pixel features distinct or similar to their neighbors and thus address the over- and under-segmentation problems. We perform experiments on five different EM datasets where our proposed method yields better results than several strong baselines. More importantly, by using non-local correlation, we observe fewer false separations within one cell and fewer false fusions between cells. Cold Spring Harbor Laboratory 2023-01-25 /pmc/articles/PMC9900774/ /pubmed/36747649 http://dx.doi.org/10.1101/2023.01.24.525387 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Duan, Bin
Cao, Jianfeng
Wang, Wei
Cai, Dawen
Yan, Yan
CELL INSTANCE SEGMENTATION VIA MULTI-SCALE NON-LOCAL CORRELATION
title CELL INSTANCE SEGMENTATION VIA MULTI-SCALE NON-LOCAL CORRELATION
title_full CELL INSTANCE SEGMENTATION VIA MULTI-SCALE NON-LOCAL CORRELATION
title_fullStr CELL INSTANCE SEGMENTATION VIA MULTI-SCALE NON-LOCAL CORRELATION
title_full_unstemmed CELL INSTANCE SEGMENTATION VIA MULTI-SCALE NON-LOCAL CORRELATION
title_short CELL INSTANCE SEGMENTATION VIA MULTI-SCALE NON-LOCAL CORRELATION
title_sort cell instance segmentation via multi-scale non-local correlation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900774/
https://www.ncbi.nlm.nih.gov/pubmed/36747649
http://dx.doi.org/10.1101/2023.01.24.525387
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