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Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing
Functional magnetic resonance imaging (fMRI) has proven to be a powerful tool for noninvasively measuring human brain activity; yet, thus far, fMRI has been relatively limited in its temporal resolution. A key challenge is understanding the relationship between neural activity and the blood-oxygenat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900794/ https://www.ncbi.nlm.nih.gov/pubmed/36747821 http://dx.doi.org/10.1101/2023.01.25.525528 |
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author | Bailes, Sydney M. Gomez, Daniel E. P. Setzer, Beverly Lewis, Laura D. |
author_facet | Bailes, Sydney M. Gomez, Daniel E. P. Setzer, Beverly Lewis, Laura D. |
author_sort | Bailes, Sydney M. |
collection | PubMed |
description | Functional magnetic resonance imaging (fMRI) has proven to be a powerful tool for noninvasively measuring human brain activity; yet, thus far, fMRI has been relatively limited in its temporal resolution. A key challenge is understanding the relationship between neural activity and the blood-oxygenation-level-dependent (BOLD) signal obtained from fMRI, generally modeled by the hemodynamic response function (HRF). The timing of the HRF varies across the brain and individuals, confounding our ability to make inferences about the timing of the underlying neural processes. Here we show that resting-state fMRI signals contain information about HRF temporal dynamics that can be leveraged to understand and char-acterize variations in HRF timing across both cortical and subcortical regions. We found that the frequency spectrum of resting-state fMRI signals significantly differs between voxels with fast versus slow HRFs in human visual cortex. These spectral differences extended to subcortex as well, revealing significantly faster hemodynamic timing in the lateral geniculate nucleus of the thalamus. Ultimately, our results demonstrate that the temporal properties of the HRF impact the spectral content of resting-state fMRI signals and enable voxel-wise characterization of relative hemodynamic response timing. Furthermore, our results show that caution should be used in studies of resting-state fMRI spectral properties, as differences can arise from purely vascular origins. This finding provides new insight into the temporal properties of fMRI signals across voxels, which is crucial for accurate fMRI analyses, and enhances the ability of fast fMRI to identify and track fast neural dynamics. |
format | Online Article Text |
id | pubmed-9900794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-99007942023-02-07 Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing Bailes, Sydney M. Gomez, Daniel E. P. Setzer, Beverly Lewis, Laura D. bioRxiv Article Functional magnetic resonance imaging (fMRI) has proven to be a powerful tool for noninvasively measuring human brain activity; yet, thus far, fMRI has been relatively limited in its temporal resolution. A key challenge is understanding the relationship between neural activity and the blood-oxygenation-level-dependent (BOLD) signal obtained from fMRI, generally modeled by the hemodynamic response function (HRF). The timing of the HRF varies across the brain and individuals, confounding our ability to make inferences about the timing of the underlying neural processes. Here we show that resting-state fMRI signals contain information about HRF temporal dynamics that can be leveraged to understand and char-acterize variations in HRF timing across both cortical and subcortical regions. We found that the frequency spectrum of resting-state fMRI signals significantly differs between voxels with fast versus slow HRFs in human visual cortex. These spectral differences extended to subcortex as well, revealing significantly faster hemodynamic timing in the lateral geniculate nucleus of the thalamus. Ultimately, our results demonstrate that the temporal properties of the HRF impact the spectral content of resting-state fMRI signals and enable voxel-wise characterization of relative hemodynamic response timing. Furthermore, our results show that caution should be used in studies of resting-state fMRI spectral properties, as differences can arise from purely vascular origins. This finding provides new insight into the temporal properties of fMRI signals across voxels, which is crucial for accurate fMRI analyses, and enhances the ability of fast fMRI to identify and track fast neural dynamics. Cold Spring Harbor Laboratory 2023-01-26 /pmc/articles/PMC9900794/ /pubmed/36747821 http://dx.doi.org/10.1101/2023.01.25.525528 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Bailes, Sydney M. Gomez, Daniel E. P. Setzer, Beverly Lewis, Laura D. Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing |
title | Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing |
title_full | Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing |
title_fullStr | Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing |
title_full_unstemmed | Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing |
title_short | Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing |
title_sort | resting-state fmri signals contain spectral signatures of local hemodynamic response timing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900794/ https://www.ncbi.nlm.nih.gov/pubmed/36747821 http://dx.doi.org/10.1101/2023.01.25.525528 |
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