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PIC recruitment by synthetic reader-actuators to polycomb-silenced genes blocks triple-negative breast cancer invasion

Scientists have used small molecule inhibitors and genetic knockdown of gene-silencing polycomb repressive complexes (PRC1/2) to determine if restoring the expression of tumor suppressor genes can block proliferation and invasion of cancer cells. A major limitation of this approach is that inhibitor...

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Detalles Bibliográficos
Autores principales: Williams, Natecia L., Hong, Lauren, Jaffe, Maya, Shields, Cara E., Haynes, Karmella A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900809/
https://www.ncbi.nlm.nih.gov/pubmed/36747762
http://dx.doi.org/10.1101/2023.01.23.525196

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