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Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth

Delay discounting is a measure of impulsive choice relevant in adolescence as it predicts many real-life outcomes, including substance use disorders, obesity, and academic achievement. However, the functional networks underlying individual differences in delay discounting during youth remain incompl...

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Autores principales: Mehta, Kahini, Pines, Adam, Adebimpe, Azeez, Larsen, Bart, Bassett, Dani S., Calkins, Monica E., Baller, Erica, Gell, Martin, Patrick, Lauren M., Gur, Raquel E., Gur, Ruben C., Roalf, David R., Romer, Daniel, Wolf, Daniel H., Kable, Joseph W., Satterthwaite, Theodore D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900814/
https://www.ncbi.nlm.nih.gov/pubmed/36747838
http://dx.doi.org/10.1101/2023.01.25.525577
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author Mehta, Kahini
Pines, Adam
Adebimpe, Azeez
Larsen, Bart
Bassett, Dani S.
Calkins, Monica E.
Baller, Erica
Gell, Martin
Patrick, Lauren M.
Gur, Raquel E.
Gur, Ruben C.
Roalf, David R.
Romer, Daniel
Wolf, Daniel H.
Kable, Joseph W.
Satterthwaite, Theodore D.
author_facet Mehta, Kahini
Pines, Adam
Adebimpe, Azeez
Larsen, Bart
Bassett, Dani S.
Calkins, Monica E.
Baller, Erica
Gell, Martin
Patrick, Lauren M.
Gur, Raquel E.
Gur, Ruben C.
Roalf, David R.
Romer, Daniel
Wolf, Daniel H.
Kable, Joseph W.
Satterthwaite, Theodore D.
author_sort Mehta, Kahini
collection PubMed
description Delay discounting is a measure of impulsive choice relevant in adolescence as it predicts many real-life outcomes, including substance use disorders, obesity, and academic achievement. However, the functional networks underlying individual differences in delay discounting during youth remain incompletely described. Here we investigate the association between multivariate patterns of functional connectivity and individual differences in impulsive choice in a large sample of youth. A total of 293 youth (9-23 years) completed a delay discounting task and underwent resting-state fMRI at 3T. A connectome-wide analysis using multivariate distance-based matrix regression was used to examine whole-brain relationships between delay discounting and functional connectivity was then performed. These analyses revealed that individual differences in delay discounting were associated with patterns of connectivity emanating from the left dorsal prefrontal cortex, a hub of the default mode network. Delay discounting was associated with greater functional connectivity between the dorsal prefrontal cortex and other parts of the default mode network, and reduced connectivity with regions in the dorsal and ventral attention networks. These results suggest that delay discounting in youth is associated with individual differences in relationships both within the default mode network and between the default mode and networks involved in attentional and cognitive control.
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spelling pubmed-99008142023-02-07 Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth Mehta, Kahini Pines, Adam Adebimpe, Azeez Larsen, Bart Bassett, Dani S. Calkins, Monica E. Baller, Erica Gell, Martin Patrick, Lauren M. Gur, Raquel E. Gur, Ruben C. Roalf, David R. Romer, Daniel Wolf, Daniel H. Kable, Joseph W. Satterthwaite, Theodore D. bioRxiv Article Delay discounting is a measure of impulsive choice relevant in adolescence as it predicts many real-life outcomes, including substance use disorders, obesity, and academic achievement. However, the functional networks underlying individual differences in delay discounting during youth remain incompletely described. Here we investigate the association between multivariate patterns of functional connectivity and individual differences in impulsive choice in a large sample of youth. A total of 293 youth (9-23 years) completed a delay discounting task and underwent resting-state fMRI at 3T. A connectome-wide analysis using multivariate distance-based matrix regression was used to examine whole-brain relationships between delay discounting and functional connectivity was then performed. These analyses revealed that individual differences in delay discounting were associated with patterns of connectivity emanating from the left dorsal prefrontal cortex, a hub of the default mode network. Delay discounting was associated with greater functional connectivity between the dorsal prefrontal cortex and other parts of the default mode network, and reduced connectivity with regions in the dorsal and ventral attention networks. These results suggest that delay discounting in youth is associated with individual differences in relationships both within the default mode network and between the default mode and networks involved in attentional and cognitive control. Cold Spring Harbor Laboratory 2023-01-26 /pmc/articles/PMC9900814/ /pubmed/36747838 http://dx.doi.org/10.1101/2023.01.25.525577 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Mehta, Kahini
Pines, Adam
Adebimpe, Azeez
Larsen, Bart
Bassett, Dani S.
Calkins, Monica E.
Baller, Erica
Gell, Martin
Patrick, Lauren M.
Gur, Raquel E.
Gur, Ruben C.
Roalf, David R.
Romer, Daniel
Wolf, Daniel H.
Kable, Joseph W.
Satterthwaite, Theodore D.
Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth
title Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth
title_full Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth
title_fullStr Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth
title_full_unstemmed Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth
title_short Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth
title_sort individual differences in delay discounting are associated with dorsal prefrontal cortex connectivity in youth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900814/
https://www.ncbi.nlm.nih.gov/pubmed/36747838
http://dx.doi.org/10.1101/2023.01.25.525577
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