Cardiomyocyte apoptosis contributes to contractile dysfunction in stem cell model of MYH7 E848G hypertrophic cardiomyopathy

Missense mutations in myosin heavy chain 7 (MYH7) are a common cause of hypertrophic cardiomyopathy (HCM), but the molecular mechanisms underlying MYH7-based HCM remain unclear. In this work, we generated cardiomyocytes derived from isogenic human induced pluripotent stem cells to model the heterozy...

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Detalles Bibliográficos
Autores principales: Loiben, Alexander M., Chien, Wei-Ming, Friedman, Clayton E., Chao, Leslie S-L., Weber, Gerhard, Goldstein, Alex, Sniadecki, Nathan, Murry, Charles E., Yang, Kai-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900838/
https://www.ncbi.nlm.nih.gov/pubmed/36747800
http://dx.doi.org/10.1101/2023.01.24.525458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900838/
https://www.ncbi.nlm.nih.gov/pubmed/36747800
http://dx.doi.org/10.1101/2023.01.24.525458

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