Compressed phenotypic screens for complex multicellular models and high-content assays

High-throughput phenotypic screens leveraging biochemical perturbations, high-content readouts, and complex multicellular models could advance therapeutic discovery yet remain constrained by limitations of scale. To address this, we establish a method for compressing screens by pooling perturbations...

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Detalles Bibliográficos
Autores principales: Mead, Benjamin E., Kummerlowe, Conner, Liu, Nuo, Kattan, Walaa E., Cheng, Thomas, Cheah, Jaime H., Soule, Christian K., Peters, Josh, Lowder, Kristen E., Blainey, Paul C., Hahn, William C., Cleary, Brian, Bryson, Bryan, Winter, Peter S., Raghavan, Srivatsan, Shalek, Alex K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900857/
https://www.ncbi.nlm.nih.gov/pubmed/36747859
http://dx.doi.org/10.1101/2023.01.23.525189

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