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Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblasts

Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient, with heterogeneity among transcription factor (TF) trajectories driving divergent cell states. Nevertheless, the impact of TF dynamics on reprogramming efficiency remains uncharted. Here, we identify the succes...

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Detalles Bibliográficos
Autores principales:	Ilia, Katherine, Shakiba, Nika, Bingham, Trevor, Jones, Ross D., Kaminski, Michael M., Aravera, Eliezer, Bruno, Simone, Palacios, Sebastian, Weiss, Ron, Collins, James J., Del Vecchio, Domitilla, Schlaeger, Thorsten M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900859/ https://www.ncbi.nlm.nih.gov/pubmed/36747813 http://dx.doi.org/10.1101/2023.01.25.525529

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