A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells

FLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper vessel morphogenesis during vascular development and vessel homeostasis. Although a soluble isoform, sFLT1, is often mis-regulated in disease and aging, how sFLT1 is trafficked and secreted from endothelial cells is not wel...

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Detalles Bibliográficos
Autores principales: Kinghorn, Karina, Gill, Amy, Marvin, Allison, Li, Renee, Quigley, Kaitlyn, le Noble, Ferdinand, Mac Gabhann, Feilim, Bautch, Victoria L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900880/
https://www.ncbi.nlm.nih.gov/pubmed/36747809
http://dx.doi.org/10.1101/2023.01.27.525517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900880/
https://www.ncbi.nlm.nih.gov/pubmed/36747809
http://dx.doi.org/10.1101/2023.01.27.525517

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