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A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
FLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper vessel morphogenesis during vascular development and vessel homeostasis. Although a soluble isoform, sFLT1, is often mis-regulated in disease and aging, how sFLT1 is trafficked and secreted from endothelial cells is not wel...
Autores principales: | Kinghorn, Karina, Gill, Amy, Marvin, Allison, Li, Renee, Quigley, Kaitlyn, le Noble, Ferdinand, Mac Gabhann, Feilim, Bautch, Victoria L |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900880/ https://www.ncbi.nlm.nih.gov/pubmed/36747809 http://dx.doi.org/10.1101/2023.01.27.525517 |
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