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Hyperextended telomeres promote C-circle formation in telomerase positive human cells

Telomere length maintenance is crucial to cancer cell immortality. Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). The primary ALT biomarker is the C-circle, a type of circular DNA with extrachromosomal telomere...

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Detalles Bibliográficos
Autores principales:	Jones, Celina Y., Williams, Christopher L., Moreno, Sara P., Morris, Danna K., Mondello, Chiara, Karlseder, Jan, Bertuch, Alison A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900909/ https://www.ncbi.nlm.nih.gov/pubmed/36747763 http://dx.doi.org/10.1101/2023.01.26.525615

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