Cargando…

Using mechanistic models and machine learning to design single-color multiplexed Nascent Chain Tracking experiments

Mostrar otras versiones (1)

mRNA translation is the ubiquitous cellular process of reading messenger-RNA strands into functional proteins. Over the past decade, large strides in microscopy techniques have allowed observation of mRNA translation at a single-molecule resolution for self-consistent time-series measurements in liv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raymond, William S., Ghaffari, Sadaf, Aguilera, Luis U., Ron, Eric, Morisaki, Tatsuya, Fox, Zachary R., May, Michael P., Stasevich, Timothy J., Munsky, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900927/ https://www.ncbi.nlm.nih.gov/pubmed/36747627 http://dx.doi.org/10.1101/2023.01.25.525583

Ejemplares similares

Using mechanistic models and machine learning to design single-color multiplexed nascent chain tracking experiments
por: Raymond, William S., et al.
Publicado: (2023)

Computational design and interpretation of single-RNA translation experiments
por: Aguilera, Luis U., et al.
Publicado: (2019)

A genetically encoded probe for imaging nascent and mature HA-tagged proteins in vivo
por: Zhao, Ning, et al.
Publicado: (2019)

Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene
por: Forero-Quintero, Linda S., et al.
Publicado: (2021)

Multicolor single-molecule tracking of mRNA interactions with RNP granules
por: Moon, Stephanie L., et al.
Publicado: (2019)

Nascent chain dynamics and ribosome interactions within folded ribosome–nascent chain complexes observed by NMR spectroscopy
por: Burridge, Charles, et al.
Publicado: (2021)

Birth, life and death of nascent polypeptide chains
por: Jha, Sujata, et al.
Publicado: (2011)

Statistical Evidence for a Helical Nascent Chain
por: Cruzeiro, Leonor, et al.
Publicado: (2021)

Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest
por: Muta, Mikihisa, et al.
Publicado: (2020)

The finite state projection based Fisher information matrix approach to estimate information and optimize single-cell experiments
por: Fox, Zachary R, et al.
Publicado: (2019)

Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins
por: Hansen, William J., et al.
Publicado: (1999)

Ribosomes have a NAC for nascent chain processing
por: Short, Ben
Publicado: (2015)

Coupling of translation quality control and mRNA targeting to stress granules
por: Moon, Stephanie L., et al.
Publicado: (2020)

Nuclear translation visualized by ribosome-bound nascent chain puromycylation
por: David, Alexandre, et al.
Publicado: (2012)

NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center
Publicado: (1995)

Live-cell imaging uncovers the relationship between histone acetylation, transcription initiation, and nucleosome mobility
por: Saxton, Matthew N., et al.
Publicado: (2023)

Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex
por: Nilsson, IngMarie, et al.
Publicado: (2003)

Nonorthogonal tRNA(cys)(Amber) for protein and nascent chain labeling
por: Koubek, Jiří, et al.
Publicado: (2015)

Nascent SecM Chain Outside the Ribosome Reinforces Translation Arrest
por: Yang, Zhuohao, et al.
Publicado: (2015)

Partially inserted nascent chain unzips the lateral gate of the Sec translocon
por: Kater, Lukas, et al.
Publicado: (2019)

pSNAP: Proteome-wide analysis of elongating nascent polypeptide chains
por: Uchiyama, Junki, et al.
Publicado: (2022)

Nascent Chain Ubiquitination is Uncoupled from Degradation to Enable Protein Maturation
por: Li, Xia, et al.
Publicado: (2023)

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas
Publicado: (1986)

Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes
Publicado: (1993)

Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation
Publicado: (1989)

A Mechanism for Adding the First Link in a Nascent Actin Filament Chain
Publicado: (2004)

Charge-driven dynamics of nascent chain movement through the SecYEG translocon
por: Ismail, Nurzian, et al.
Publicado: (2015)

Common sequence motifs of nascent chains engage the ribosome surface and trigger factor
por: Deckert, Annika, et al.
Publicado: (2021)

Immunoprecipitation of Reporter Nascent Chains from Active Ribosomes to Study Translation Efficiency
por: Cacioppo, Roberta, et al.
Publicado: (2023)

Building predictive signaling models by perturbing yeast cells with time-varying stimulations resulting in distinct signaling responses
por: Jashnsaz, Hossein, et al.
Publicado: (2021)

Vms1/Ankzf1 peptidyl-tRNA hydrolase releases nascent chains from stalled ribosomes
por: Verma, Rati, et al.
Publicado: (2018)

Imaging translational control by Argonaute with single-molecule resolution in live cells
por: Cialek, Charlotte A., et al.
Publicado: (2022)

Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes
Publicado: (1983)

Identification of a Novel Stage of Ribosome/Nascent Chain Association with the Endoplasmic Reticulum Membrane
por: Murphy, Edwin C., et al.
Publicado: (1997)

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
por: Lintner, Nathanael G., et al.
Publicado: (2017)

Elongation inhibitors do not prevent the release of puromycylated nascent polypeptide chains from ribosomes
por: Hobson, Benjamin D, et al.
Publicado: (2020)

The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb
por: Zhang, Ying, et al.
Publicado: (2020)

She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain
por: Ecklund, Kari H., et al.
Publicado: (2017)

Incorporation of nascent myosin heavy chains into thick filaments of cardiac myocytes in thyroid-treated rabbits
Publicado: (1987)

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
por: Hanebuth, Marie A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_e5o67ubjlpevm6bbcr29st7gnn