Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Pancreatic intraepithelial neoplasia (PanIN) is a precursor to pancreatic cancer and represents a critical opportunity for cancer interception. However, the number, size, shape, and connectivity of PanINs in human pancreatic tissue samples are largely unknown. In this study, we quantitatively assess...

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Detalles Bibliográficos
Autores principales: Braxton, Alicia M, Kiemen, Ashley L, Grahn, Mia P, Forjaz, André, Babu, Jaanvi Mahesh, Zheng, Lily, Jiang, Liping, Cheng, Haixia, Song, Qianqian, Reichel, Rebecca, Graham, Sarah, Damanakis, Alexander I, Fischer, Catherine G, Mou, Stephanie, Metz, Cameron, Granger, Julie, Liu, Xiao-Ding, Bachmann, Niklas, Almagro-Pérez, Cristina, Jiang, Ann Chenyu, Yoo, Jeonghyun, Kim, Bridgette, Du, Scott, Foster, Eli, Hsu, Jocelyn Y, Rivera, Paula Andreu, Chu, Linda C, Liu, Fengze, Niknafs, Noushin, Fishman, Elliot K, Yuille, Alan, Roberts, Nicholas J, Thompson, Elizabeth D, Scharpf, Robert B, Cornish, Toby C, Jiao, Yuchen, Karchin, Rachel, Hruban, Ralph H, Wu, Pei-Hsun, Wirtz, Denis, Wood, Laura D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900989/
https://www.ncbi.nlm.nih.gov/pubmed/36747709
http://dx.doi.org/10.1101/2023.01.27.525553

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