Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[(18)F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA receptors

GluN2B subunit-containing N-methyl-d-aspartate (NMDA) receptors have been implicated in various neurological disorders. Nonetheless, a validated fluorine-18 labeled positron emission tomography (PET) ligand for GluN2B imaging in the living human brain is currently lacking. As part of our PET ligand...

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Detalles Bibliográficos
Autores principales: Korff, Marvin, Chaudhary, Ahmad, Li, Yinlong, Zhou, Xin, Zhao, Chunyu, Rong, Jian, Chen, Jiahui, Xiao, Zhiwei, Elghazawy, Nehal H., Sippl, Wolfgang, Davenport, April T., Daunais, James B., Wang, Lu, Abate, Carmen, Ahmed, Hazem, Crowe, Ron, Liang, Steven H., Ametamey, Simon M., Wünsch, Bernhard, Haider, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901044/
https://www.ncbi.nlm.nih.gov/pubmed/36747738
http://dx.doi.org/10.21203/rs.3.rs-2516002/v1

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