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AgNOR patterns and configurations in adult acute leukemia patients

The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor of tumor recurrence, while research into acute leukemias is scarce...

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Autores principales: Gajewska, Małgorzata, Kwiecień, Iwona, Rutkowska, Elżbieta, Rzepecki, Piotr, Sułek, Kazimierz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901258/
https://www.ncbi.nlm.nih.gov/pubmed/36817394
http://dx.doi.org/10.5114/ceji.2022.124252
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author Gajewska, Małgorzata
Kwiecień, Iwona
Rutkowska, Elżbieta
Rzepecki, Piotr
Sułek, Kazimierz
author_facet Gajewska, Małgorzata
Kwiecień, Iwona
Rutkowska, Elżbieta
Rzepecki, Piotr
Sułek, Kazimierz
author_sort Gajewska, Małgorzata
collection PubMed
description The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor of tumor recurrence, while research into acute leukemias is scarce. The aim of the study was to determine whether the assessment of AgNOR parameters is useful in the differentiation of acute leukemias and, together with cytogenetic changes, would allow for a quick evaluation of the risk group. The AgNOR structures were analyzed in terms of the shape, surface area and distribution in bone marrow blast cells in patients with acute leukemias. We observed significant differences in the AgNOR structures, simple, compound and complex patterns between acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Complex structures were more numerous in ALL than in AML patients. There were significant differences in the distribution of AgNOR configuration among various cytogenetic AML risk groups. We observed a significant difference in the mean number of AgNOR between ALL-T and ALL-B. We detected diversity in the AgNOR structures and pattern map in AML and ALL. Thus, presentation of a variety of AgNOR configurations is innovative and can be a useful method of differentiating patients with acute leukemia types and cytogenetic risk.
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spelling pubmed-99012582023-02-16 AgNOR patterns and configurations in adult acute leukemia patients Gajewska, Małgorzata Kwiecień, Iwona Rutkowska, Elżbieta Rzepecki, Piotr Sułek, Kazimierz Cent Eur J Immunol Clinical Immunology The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor of tumor recurrence, while research into acute leukemias is scarce. The aim of the study was to determine whether the assessment of AgNOR parameters is useful in the differentiation of acute leukemias and, together with cytogenetic changes, would allow for a quick evaluation of the risk group. The AgNOR structures were analyzed in terms of the shape, surface area and distribution in bone marrow blast cells in patients with acute leukemias. We observed significant differences in the AgNOR structures, simple, compound and complex patterns between acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Complex structures were more numerous in ALL than in AML patients. There were significant differences in the distribution of AgNOR configuration among various cytogenetic AML risk groups. We observed a significant difference in the mean number of AgNOR between ALL-T and ALL-B. We detected diversity in the AgNOR structures and pattern map in AML and ALL. Thus, presentation of a variety of AgNOR configurations is innovative and can be a useful method of differentiating patients with acute leukemia types and cytogenetic risk. Termedia Publishing House 2023-01-31 2022 /pmc/articles/PMC9901258/ /pubmed/36817394 http://dx.doi.org/10.5114/ceji.2022.124252 Text en Copyright © 2022 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Clinical Immunology
Gajewska, Małgorzata
Kwiecień, Iwona
Rutkowska, Elżbieta
Rzepecki, Piotr
Sułek, Kazimierz
AgNOR patterns and configurations in adult acute leukemia patients
title AgNOR patterns and configurations in adult acute leukemia patients
title_full AgNOR patterns and configurations in adult acute leukemia patients
title_fullStr AgNOR patterns and configurations in adult acute leukemia patients
title_full_unstemmed AgNOR patterns and configurations in adult acute leukemia patients
title_short AgNOR patterns and configurations in adult acute leukemia patients
title_sort agnor patterns and configurations in adult acute leukemia patients
topic Clinical Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901258/
https://www.ncbi.nlm.nih.gov/pubmed/36817394
http://dx.doi.org/10.5114/ceji.2022.124252
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