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AgNOR patterns and configurations in adult acute leukemia patients
The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor of tumor recurrence, while research into acute leukemias is scarce...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901258/ https://www.ncbi.nlm.nih.gov/pubmed/36817394 http://dx.doi.org/10.5114/ceji.2022.124252 |
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author | Gajewska, Małgorzata Kwiecień, Iwona Rutkowska, Elżbieta Rzepecki, Piotr Sułek, Kazimierz |
author_facet | Gajewska, Małgorzata Kwiecień, Iwona Rutkowska, Elżbieta Rzepecki, Piotr Sułek, Kazimierz |
author_sort | Gajewska, Małgorzata |
collection | PubMed |
description | The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor of tumor recurrence, while research into acute leukemias is scarce. The aim of the study was to determine whether the assessment of AgNOR parameters is useful in the differentiation of acute leukemias and, together with cytogenetic changes, would allow for a quick evaluation of the risk group. The AgNOR structures were analyzed in terms of the shape, surface area and distribution in bone marrow blast cells in patients with acute leukemias. We observed significant differences in the AgNOR structures, simple, compound and complex patterns between acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Complex structures were more numerous in ALL than in AML patients. There were significant differences in the distribution of AgNOR configuration among various cytogenetic AML risk groups. We observed a significant difference in the mean number of AgNOR between ALL-T and ALL-B. We detected diversity in the AgNOR structures and pattern map in AML and ALL. Thus, presentation of a variety of AgNOR configurations is innovative and can be a useful method of differentiating patients with acute leukemia types and cytogenetic risk. |
format | Online Article Text |
id | pubmed-9901258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-99012582023-02-16 AgNOR patterns and configurations in adult acute leukemia patients Gajewska, Małgorzata Kwiecień, Iwona Rutkowska, Elżbieta Rzepecki, Piotr Sułek, Kazimierz Cent Eur J Immunol Clinical Immunology The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor of tumor recurrence, while research into acute leukemias is scarce. The aim of the study was to determine whether the assessment of AgNOR parameters is useful in the differentiation of acute leukemias and, together with cytogenetic changes, would allow for a quick evaluation of the risk group. The AgNOR structures were analyzed in terms of the shape, surface area and distribution in bone marrow blast cells in patients with acute leukemias. We observed significant differences in the AgNOR structures, simple, compound and complex patterns between acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Complex structures were more numerous in ALL than in AML patients. There were significant differences in the distribution of AgNOR configuration among various cytogenetic AML risk groups. We observed a significant difference in the mean number of AgNOR between ALL-T and ALL-B. We detected diversity in the AgNOR structures and pattern map in AML and ALL. Thus, presentation of a variety of AgNOR configurations is innovative and can be a useful method of differentiating patients with acute leukemia types and cytogenetic risk. Termedia Publishing House 2023-01-31 2022 /pmc/articles/PMC9901258/ /pubmed/36817394 http://dx.doi.org/10.5114/ceji.2022.124252 Text en Copyright © 2022 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Clinical Immunology Gajewska, Małgorzata Kwiecień, Iwona Rutkowska, Elżbieta Rzepecki, Piotr Sułek, Kazimierz AgNOR patterns and configurations in adult acute leukemia patients |
title | AgNOR patterns and configurations in adult acute leukemia patients |
title_full | AgNOR patterns and configurations in adult acute leukemia patients |
title_fullStr | AgNOR patterns and configurations in adult acute leukemia patients |
title_full_unstemmed | AgNOR patterns and configurations in adult acute leukemia patients |
title_short | AgNOR patterns and configurations in adult acute leukemia patients |
title_sort | agnor patterns and configurations in adult acute leukemia patients |
topic | Clinical Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901258/ https://www.ncbi.nlm.nih.gov/pubmed/36817394 http://dx.doi.org/10.5114/ceji.2022.124252 |
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