Acute Cardiac Events During COVID-19-Associated Hospitalizations

BACKGROUND: COVID-19 is associated with cardiac complications. OBJECTIVES: The purpose of this study was to estimate the prevalence, risk factors, and outcomes associated with acute cardiac events during COVID-19-associated hospitalizations among adults. METHODS: During January 2021 to November 2021...

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Detalles Bibliográficos
Autores principales: Woodruff, Rebecca C., Garg, Shikha, George, Mary G., Patel, Kadam, Jackson, Sandra L., Loustalot, Fleetwood, Wortham, Jonathan M., Taylor, Christopher A., Whitaker, Michael, Reingold, Arthur, Alden, Nisha B., Meek, James, Anderson, Evan J., Weigel, Andy, Henderson, Justin, Bye, Erica, Davis, Sarah Shrum, Barney, Grant, Bennett, Nancy M., Shiltz, Eli, Sutton, Melissa, Talbot, H. Keipp, Price, Andrea, Sperling, Laurence S., Havers, Fiona P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Biomedical 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901494/
https://www.ncbi.nlm.nih.gov/pubmed/36754516
http://dx.doi.org/10.1016/j.jacc.2022.11.044
Descripción
Sumario:BACKGROUND: COVID-19 is associated with cardiac complications. OBJECTIVES: The purpose of this study was to estimate the prevalence, risk factors, and outcomes associated with acute cardiac events during COVID-19-associated hospitalizations among adults. METHODS: During January 2021 to November 2021, medical chart abstraction was conducted on a probability sample of adults hospitalized with laboratory-confirmed SARS-CoV-2 infection identified from 99 U.S. counties in 14 U.S. states in the COVID-19-Associated Hospitalization Surveillance Network. We calculated the prevalence of acute cardiac events (identified by International Classification of Diseases-10th Revision-Clinical Modification codes) by history of underlying cardiac disease and examined associated risk factors and disease outcomes. RESULTS: Among 8,460 adults, 11.4% (95% CI: 10.1%-12.9%) experienced an acute cardiac event during a COVID-19-associated hospitalization. Prevalence was higher among adults who had underlying cardiac disease (23.4%; 95% CI: 20.7%-26.3%) compared with those who did not (6.2%; 95% CI: 5.1%-7.6%). Acute ischemic heart disease (5.5%; 95% CI: 4.5%-6.5%) and acute heart failure (5.4%; 95% CI: 4.4%-6.6%) were the most prevalent events; 0.3% (95% CI: 0.1%-0.5%) experienced acute myocarditis or pericarditis. Risk factors varied by underlying cardiac disease status. Patients with ≥1 acute cardiac event had greater risk of intensive care unit admission (adjusted risk ratio: 1.9; 95% CI: 1.8-2.1) and in-hospital death (adjusted risk ratio: 1.7; 95% CI: 1.3-2.1) compared with those who did not. CONCLUSIONS: Acute cardiac events were common during COVID-19-associated hospitalizations, particularly among patients with underlying cardiac disease, and are associated with severe disease outcomes. Persons at greater risk for experiencing acute cardiac events during COVID-19-associated hospitalizations might benefit from more intensive clinical evaluation and monitoring during hospitalization.

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