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Acute Cardiac Events During COVID-19-Associated Hospitalizations

BACKGROUND: COVID-19 is associated with cardiac complications. OBJECTIVES: The purpose of this study was to estimate the prevalence, risk factors, and outcomes associated with acute cardiac events during COVID-19-associated hospitalizations among adults. METHODS: During January 2021 to November 2021...

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Autores principales: Woodruff, Rebecca C., Garg, Shikha, George, Mary G., Patel, Kadam, Jackson, Sandra L., Loustalot, Fleetwood, Wortham, Jonathan M., Taylor, Christopher A., Whitaker, Michael, Reingold, Arthur, Alden, Nisha B., Meek, James, Anderson, Evan J., Weigel, Andy, Henderson, Justin, Bye, Erica, Davis, Sarah Shrum, Barney, Grant, Bennett, Nancy M., Shiltz, Eli, Sutton, Melissa, Talbot, H. Keipp, Price, Andrea, Sperling, Laurence S., Havers, Fiona P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Biomedical 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901494/
https://www.ncbi.nlm.nih.gov/pubmed/36754516
http://dx.doi.org/10.1016/j.jacc.2022.11.044
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author Woodruff, Rebecca C.
Garg, Shikha
George, Mary G.
Patel, Kadam
Jackson, Sandra L.
Loustalot, Fleetwood
Wortham, Jonathan M.
Taylor, Christopher A.
Whitaker, Michael
Reingold, Arthur
Alden, Nisha B.
Meek, James
Anderson, Evan J.
Weigel, Andy
Henderson, Justin
Bye, Erica
Davis, Sarah Shrum
Barney, Grant
Bennett, Nancy M.
Shiltz, Eli
Sutton, Melissa
Talbot, H. Keipp
Price, Andrea
Sperling, Laurence S.
Havers, Fiona P.
author_facet Woodruff, Rebecca C.
Garg, Shikha
George, Mary G.
Patel, Kadam
Jackson, Sandra L.
Loustalot, Fleetwood
Wortham, Jonathan M.
Taylor, Christopher A.
Whitaker, Michael
Reingold, Arthur
Alden, Nisha B.
Meek, James
Anderson, Evan J.
Weigel, Andy
Henderson, Justin
Bye, Erica
Davis, Sarah Shrum
Barney, Grant
Bennett, Nancy M.
Shiltz, Eli
Sutton, Melissa
Talbot, H. Keipp
Price, Andrea
Sperling, Laurence S.
Havers, Fiona P.
author_sort Woodruff, Rebecca C.
collection PubMed
description BACKGROUND: COVID-19 is associated with cardiac complications. OBJECTIVES: The purpose of this study was to estimate the prevalence, risk factors, and outcomes associated with acute cardiac events during COVID-19-associated hospitalizations among adults. METHODS: During January 2021 to November 2021, medical chart abstraction was conducted on a probability sample of adults hospitalized with laboratory-confirmed SARS-CoV-2 infection identified from 99 U.S. counties in 14 U.S. states in the COVID-19-Associated Hospitalization Surveillance Network. We calculated the prevalence of acute cardiac events (identified by International Classification of Diseases-10th Revision-Clinical Modification codes) by history of underlying cardiac disease and examined associated risk factors and disease outcomes. RESULTS: Among 8,460 adults, 11.4% (95% CI: 10.1%-12.9%) experienced an acute cardiac event during a COVID-19-associated hospitalization. Prevalence was higher among adults who had underlying cardiac disease (23.4%; 95% CI: 20.7%-26.3%) compared with those who did not (6.2%; 95% CI: 5.1%-7.6%). Acute ischemic heart disease (5.5%; 95% CI: 4.5%-6.5%) and acute heart failure (5.4%; 95% CI: 4.4%-6.6%) were the most prevalent events; 0.3% (95% CI: 0.1%-0.5%) experienced acute myocarditis or pericarditis. Risk factors varied by underlying cardiac disease status. Patients with ≥1 acute cardiac event had greater risk of intensive care unit admission (adjusted risk ratio: 1.9; 95% CI: 1.8-2.1) and in-hospital death (adjusted risk ratio: 1.7; 95% CI: 1.3-2.1) compared with those who did not. CONCLUSIONS: Acute cardiac events were common during COVID-19-associated hospitalizations, particularly among patients with underlying cardiac disease, and are associated with severe disease outcomes. Persons at greater risk for experiencing acute cardiac events during COVID-19-associated hospitalizations might benefit from more intensive clinical evaluation and monitoring during hospitalization.
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spelling pubmed-99014942023-02-07 Acute Cardiac Events During COVID-19-Associated Hospitalizations Woodruff, Rebecca C. Garg, Shikha George, Mary G. Patel, Kadam Jackson, Sandra L. Loustalot, Fleetwood Wortham, Jonathan M. Taylor, Christopher A. Whitaker, Michael Reingold, Arthur Alden, Nisha B. Meek, James Anderson, Evan J. Weigel, Andy Henderson, Justin Bye, Erica Davis, Sarah Shrum Barney, Grant Bennett, Nancy M. Shiltz, Eli Sutton, Melissa Talbot, H. Keipp Price, Andrea Sperling, Laurence S. Havers, Fiona P. J Am Coll Cardiol Original Investigation BACKGROUND: COVID-19 is associated with cardiac complications. OBJECTIVES: The purpose of this study was to estimate the prevalence, risk factors, and outcomes associated with acute cardiac events during COVID-19-associated hospitalizations among adults. METHODS: During January 2021 to November 2021, medical chart abstraction was conducted on a probability sample of adults hospitalized with laboratory-confirmed SARS-CoV-2 infection identified from 99 U.S. counties in 14 U.S. states in the COVID-19-Associated Hospitalization Surveillance Network. We calculated the prevalence of acute cardiac events (identified by International Classification of Diseases-10th Revision-Clinical Modification codes) by history of underlying cardiac disease and examined associated risk factors and disease outcomes. RESULTS: Among 8,460 adults, 11.4% (95% CI: 10.1%-12.9%) experienced an acute cardiac event during a COVID-19-associated hospitalization. Prevalence was higher among adults who had underlying cardiac disease (23.4%; 95% CI: 20.7%-26.3%) compared with those who did not (6.2%; 95% CI: 5.1%-7.6%). Acute ischemic heart disease (5.5%; 95% CI: 4.5%-6.5%) and acute heart failure (5.4%; 95% CI: 4.4%-6.6%) were the most prevalent events; 0.3% (95% CI: 0.1%-0.5%) experienced acute myocarditis or pericarditis. Risk factors varied by underlying cardiac disease status. Patients with ≥1 acute cardiac event had greater risk of intensive care unit admission (adjusted risk ratio: 1.9; 95% CI: 1.8-2.1) and in-hospital death (adjusted risk ratio: 1.7; 95% CI: 1.3-2.1) compared with those who did not. CONCLUSIONS: Acute cardiac events were common during COVID-19-associated hospitalizations, particularly among patients with underlying cardiac disease, and are associated with severe disease outcomes. Persons at greater risk for experiencing acute cardiac events during COVID-19-associated hospitalizations might benefit from more intensive clinical evaluation and monitoring during hospitalization. Elsevier Biomedical 2023-02-14 2023-02-06 /pmc/articles/PMC9901494/ /pubmed/36754516 http://dx.doi.org/10.1016/j.jacc.2022.11.044 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Investigation
Woodruff, Rebecca C.
Garg, Shikha
George, Mary G.
Patel, Kadam
Jackson, Sandra L.
Loustalot, Fleetwood
Wortham, Jonathan M.
Taylor, Christopher A.
Whitaker, Michael
Reingold, Arthur
Alden, Nisha B.
Meek, James
Anderson, Evan J.
Weigel, Andy
Henderson, Justin
Bye, Erica
Davis, Sarah Shrum
Barney, Grant
Bennett, Nancy M.
Shiltz, Eli
Sutton, Melissa
Talbot, H. Keipp
Price, Andrea
Sperling, Laurence S.
Havers, Fiona P.
Acute Cardiac Events During COVID-19-Associated Hospitalizations
title Acute Cardiac Events During COVID-19-Associated Hospitalizations
title_full Acute Cardiac Events During COVID-19-Associated Hospitalizations
title_fullStr Acute Cardiac Events During COVID-19-Associated Hospitalizations
title_full_unstemmed Acute Cardiac Events During COVID-19-Associated Hospitalizations
title_short Acute Cardiac Events During COVID-19-Associated Hospitalizations
title_sort acute cardiac events during covid-19-associated hospitalizations
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901494/
https://www.ncbi.nlm.nih.gov/pubmed/36754516
http://dx.doi.org/10.1016/j.jacc.2022.11.044
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