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Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model

Aorto-iliac calcification (AIC) is a well-studied risk factor for post-transplant cardiovascular events and mortality. Its effect on graft function remains unknown. The primary aim of this prospective cohort study was to assess the association between AIC and estimated glomerular filtration rate (eG...

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Autores principales: Rijkse, Elsaline, Roodnat, Joke I., Baart, Sara J., Bijdevaate, Diederik C., Dijkshoorn, Marcel L., Kimenai, Hendrikus J. A. N., van de Wetering, Jacqueline, IJzermans, Jan N. M., Minnee, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901502/
https://www.ncbi.nlm.nih.gov/pubmed/36756277
http://dx.doi.org/10.3389/ti.2023.10647
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author Rijkse, Elsaline
Roodnat, Joke I.
Baart, Sara J.
Bijdevaate, Diederik C.
Dijkshoorn, Marcel L.
Kimenai, Hendrikus J. A. N.
van de Wetering, Jacqueline
IJzermans, Jan N. M.
Minnee, Robert C.
author_facet Rijkse, Elsaline
Roodnat, Joke I.
Baart, Sara J.
Bijdevaate, Diederik C.
Dijkshoorn, Marcel L.
Kimenai, Hendrikus J. A. N.
van de Wetering, Jacqueline
IJzermans, Jan N. M.
Minnee, Robert C.
author_sort Rijkse, Elsaline
collection PubMed
description Aorto-iliac calcification (AIC) is a well-studied risk factor for post-transplant cardiovascular events and mortality. Its effect on graft function remains unknown. The primary aim of this prospective cohort study was to assess the association between AIC and estimated glomerular filtration rate (eGFR) in the first year post-transplant. Eligibility criteria were: ≥50 years of age or ≥30 years with at least one risk factor for vascular disease. A non-contrast-enhanced CT-scan was performed with quantification of AIC using the modified Agatston score. The association between AIC and eGFR was investigated with a linear mixed model adjusted for predefined variables. One-hundred-and-forty patients were included with a median of 31 (interquartile range 26–39) eGFR measurements per patient. No direct association between AIC and eGFR was found. We observed a significant interaction between follow-up time and ipsilateral AIC, indicating that patients with higher AIC scores had lower eGFR trajectory over time starting 100 days after transplant (p = 0.014). To conclude, severe AIC is not directly associated with lower post-transplant eGFR. The significant interaction indicates that patients with more severe AIC have a lower eGFR trajectory after 100 days in the first year post-transplant.
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spelling pubmed-99015022023-02-07 Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model Rijkse, Elsaline Roodnat, Joke I. Baart, Sara J. Bijdevaate, Diederik C. Dijkshoorn, Marcel L. Kimenai, Hendrikus J. A. N. van de Wetering, Jacqueline IJzermans, Jan N. M. Minnee, Robert C. Transpl Int Health Archive Aorto-iliac calcification (AIC) is a well-studied risk factor for post-transplant cardiovascular events and mortality. Its effect on graft function remains unknown. The primary aim of this prospective cohort study was to assess the association between AIC and estimated glomerular filtration rate (eGFR) in the first year post-transplant. Eligibility criteria were: ≥50 years of age or ≥30 years with at least one risk factor for vascular disease. A non-contrast-enhanced CT-scan was performed with quantification of AIC using the modified Agatston score. The association between AIC and eGFR was investigated with a linear mixed model adjusted for predefined variables. One-hundred-and-forty patients were included with a median of 31 (interquartile range 26–39) eGFR measurements per patient. No direct association between AIC and eGFR was found. We observed a significant interaction between follow-up time and ipsilateral AIC, indicating that patients with higher AIC scores had lower eGFR trajectory over time starting 100 days after transplant (p = 0.014). To conclude, severe AIC is not directly associated with lower post-transplant eGFR. The significant interaction indicates that patients with more severe AIC have a lower eGFR trajectory after 100 days in the first year post-transplant. Frontiers Media S.A. 2023-01-20 /pmc/articles/PMC9901502/ /pubmed/36756277 http://dx.doi.org/10.3389/ti.2023.10647 Text en Copyright © 2023 Rijkse, Roodnat, Baart, Bijdevaate, Dijkshoorn, Kimenai, van de Wetering, IJzermans and Minnee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Rijkse, Elsaline
Roodnat, Joke I.
Baart, Sara J.
Bijdevaate, Diederik C.
Dijkshoorn, Marcel L.
Kimenai, Hendrikus J. A. N.
van de Wetering, Jacqueline
IJzermans, Jan N. M.
Minnee, Robert C.
Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model
title Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model
title_full Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model
title_fullStr Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model
title_full_unstemmed Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model
title_short Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model
title_sort ipsilateral aorto-iliac calcification is not directly associated with egfr after kidney transplantation: a prospective cohort study analyzed using a linear mixed model
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901502/
https://www.ncbi.nlm.nih.gov/pubmed/36756277
http://dx.doi.org/10.3389/ti.2023.10647
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