Cargando…

Case Report: Chlamydia psittaci pneumonia complicated by Guillain-Barré syndrome detected using metagenomic next-generation sequencing

Psittacosis and Guillain-Barré syndrome are both rare clinical diseases with low incidence, and their combination has rarely been reported. Here, we report a case of Chlamydia psittaci pneumonia combined with Guillain-Barré syndrome. The patient initially presented with high fever, difficulty breath...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Changquan, Xu, Limin, Tan, Jiarong, Tan, Hongyi, Lin, Junhong, Zhao, Ziwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901563/
https://www.ncbi.nlm.nih.gov/pubmed/36755852
http://dx.doi.org/10.3389/fcimb.2022.1070760
_version_ 1784883050758275072
author Fang, Changquan
Xu, Limin
Tan, Jiarong
Tan, Hongyi
Lin, Junhong
Zhao, Ziwen
author_facet Fang, Changquan
Xu, Limin
Tan, Jiarong
Tan, Hongyi
Lin, Junhong
Zhao, Ziwen
author_sort Fang, Changquan
collection PubMed
description Psittacosis and Guillain-Barré syndrome are both rare clinical diseases with low incidence, and their combination has rarely been reported. Here, we report a case of Chlamydia psittaci pneumonia combined with Guillain-Barré syndrome. The patient initially presented with high fever, difficulty breathing, and fatigue. Chest computerised tomography indicated large consolidation opacities in both lungs. Metagenomic next-generation sequencing clearly identified the pathogen as C. psittaci. The patient’s fever subsided after targeted antibiotic treatment, but difficulty breathing and fatigue worsened, and the patient developed symmetric limb numbness and weakness. Lumbar puncture, electrophysiological examination, and clinical characteristics were suggestive of Guillain-Barré syndrome, and the symptoms improved after treatment with human immunoglobulin. The results of this study suggest that metagenomic next-generation sequencing is useful for the rapid diagnosis of pulmonary infectious agents. Psittacosis is closely associated with the development of Guillain-Barré syndrome; however, more cases are needed to support this conclusion, and early targeted antibiotic treatment, immunotherapy, and basic supportive treatment are essential for improving outcomes.
format Online
Article
Text
id pubmed-9901563
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-99015632023-02-07 Case Report: Chlamydia psittaci pneumonia complicated by Guillain-Barré syndrome detected using metagenomic next-generation sequencing Fang, Changquan Xu, Limin Tan, Jiarong Tan, Hongyi Lin, Junhong Zhao, Ziwen Front Cell Infect Microbiol Cellular and Infection Microbiology Psittacosis and Guillain-Barré syndrome are both rare clinical diseases with low incidence, and their combination has rarely been reported. Here, we report a case of Chlamydia psittaci pneumonia combined with Guillain-Barré syndrome. The patient initially presented with high fever, difficulty breathing, and fatigue. Chest computerised tomography indicated large consolidation opacities in both lungs. Metagenomic next-generation sequencing clearly identified the pathogen as C. psittaci. The patient’s fever subsided after targeted antibiotic treatment, but difficulty breathing and fatigue worsened, and the patient developed symmetric limb numbness and weakness. Lumbar puncture, electrophysiological examination, and clinical characteristics were suggestive of Guillain-Barré syndrome, and the symptoms improved after treatment with human immunoglobulin. The results of this study suggest that metagenomic next-generation sequencing is useful for the rapid diagnosis of pulmonary infectious agents. Psittacosis is closely associated with the development of Guillain-Barré syndrome; however, more cases are needed to support this conclusion, and early targeted antibiotic treatment, immunotherapy, and basic supportive treatment are essential for improving outcomes. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9901563/ /pubmed/36755852 http://dx.doi.org/10.3389/fcimb.2022.1070760 Text en Copyright © 2023 Fang, Xu, Tan, Tan, Lin and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Fang, Changquan
Xu, Limin
Tan, Jiarong
Tan, Hongyi
Lin, Junhong
Zhao, Ziwen
Case Report: Chlamydia psittaci pneumonia complicated by Guillain-Barré syndrome detected using metagenomic next-generation sequencing
title Case Report: Chlamydia psittaci pneumonia complicated by Guillain-Barré syndrome detected using metagenomic next-generation sequencing
title_full Case Report: Chlamydia psittaci pneumonia complicated by Guillain-Barré syndrome detected using metagenomic next-generation sequencing
title_fullStr Case Report: Chlamydia psittaci pneumonia complicated by Guillain-Barré syndrome detected using metagenomic next-generation sequencing
title_full_unstemmed Case Report: Chlamydia psittaci pneumonia complicated by Guillain-Barré syndrome detected using metagenomic next-generation sequencing
title_short Case Report: Chlamydia psittaci pneumonia complicated by Guillain-Barré syndrome detected using metagenomic next-generation sequencing
title_sort case report: chlamydia psittaci pneumonia complicated by guillain-barré syndrome detected using metagenomic next-generation sequencing
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901563/
https://www.ncbi.nlm.nih.gov/pubmed/36755852
http://dx.doi.org/10.3389/fcimb.2022.1070760
work_keys_str_mv AT fangchangquan casereportchlamydiapsittacipneumoniacomplicatedbyguillainbarresyndromedetectedusingmetagenomicnextgenerationsequencing
AT xulimin casereportchlamydiapsittacipneumoniacomplicatedbyguillainbarresyndromedetectedusingmetagenomicnextgenerationsequencing
AT tanjiarong casereportchlamydiapsittacipneumoniacomplicatedbyguillainbarresyndromedetectedusingmetagenomicnextgenerationsequencing
AT tanhongyi casereportchlamydiapsittacipneumoniacomplicatedbyguillainbarresyndromedetectedusingmetagenomicnextgenerationsequencing
AT linjunhong casereportchlamydiapsittacipneumoniacomplicatedbyguillainbarresyndromedetectedusingmetagenomicnextgenerationsequencing
AT zhaoziwen casereportchlamydiapsittacipneumoniacomplicatedbyguillainbarresyndromedetectedusingmetagenomicnextgenerationsequencing