Cargando…
The BMP inhibitor follistatin-like 1 (FSTL1) suppresses cervical carcinogenesis
Follistatin-like 1 (FSTL1) is a cancer-related matricellular secretory protein with contradictory organ-specific roles. Its contribution to the pathogenesis of cervical carcinoma is still not clear. Meanwhile, it is necessary to identify novel candidate genes to understand cervical carcinoma’s patho...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901576/ https://www.ncbi.nlm.nih.gov/pubmed/36756161 http://dx.doi.org/10.3389/fonc.2023.1100045 |
_version_ | 1784883052715966464 |
---|---|
author | Zhao, Chenjing Chen, Zhongjie Zhu, Li Miao, Yunheng Guo, Jiasen Yuan, Zhiyong Wang, Ping Li, Lian Ning, Wen |
author_facet | Zhao, Chenjing Chen, Zhongjie Zhu, Li Miao, Yunheng Guo, Jiasen Yuan, Zhiyong Wang, Ping Li, Lian Ning, Wen |
author_sort | Zhao, Chenjing |
collection | PubMed |
description | Follistatin-like 1 (FSTL1) is a cancer-related matricellular secretory protein with contradictory organ-specific roles. Its contribution to the pathogenesis of cervical carcinoma is still not clear. Meanwhile, it is necessary to identify novel candidate genes to understand cervical carcinoma’s pathogenesis further and find potential therapeutic targets. We collected cervical carcinoma samples and matched adjacent tissues from patients with the locally-advanced disease and used cervical carcinoma cell lines HeLa and C33A to evaluate the effects of FSTL1 on CC cells. The mRNA transcription and protein expression of FSTL1 in cervical carcinoma tumor biopsy tissues were lower than those of matched adjacent tissues. Patients with a lower ratio of FSTL1 mRNA between the tumor and its matched adjacent tissues showed a correlation with the advanced cervical carcinoma FIGO stages. High expression of FSTL1 markedly inhibited the proliferation, motility, and invasion of HeLa and C33A. Regarding mechanism, FSTL1 plays its role by negatively regulating the BMP4/Smad1/5/9 signaling. Our study has demonstrated the tumor suppressor effect of FSTL1, and these findings suggested a potential therapeutic target and biomarker for cervical carcinoma. |
format | Online Article Text |
id | pubmed-9901576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99015762023-02-07 The BMP inhibitor follistatin-like 1 (FSTL1) suppresses cervical carcinogenesis Zhao, Chenjing Chen, Zhongjie Zhu, Li Miao, Yunheng Guo, Jiasen Yuan, Zhiyong Wang, Ping Li, Lian Ning, Wen Front Oncol Oncology Follistatin-like 1 (FSTL1) is a cancer-related matricellular secretory protein with contradictory organ-specific roles. Its contribution to the pathogenesis of cervical carcinoma is still not clear. Meanwhile, it is necessary to identify novel candidate genes to understand cervical carcinoma’s pathogenesis further and find potential therapeutic targets. We collected cervical carcinoma samples and matched adjacent tissues from patients with the locally-advanced disease and used cervical carcinoma cell lines HeLa and C33A to evaluate the effects of FSTL1 on CC cells. The mRNA transcription and protein expression of FSTL1 in cervical carcinoma tumor biopsy tissues were lower than those of matched adjacent tissues. Patients with a lower ratio of FSTL1 mRNA between the tumor and its matched adjacent tissues showed a correlation with the advanced cervical carcinoma FIGO stages. High expression of FSTL1 markedly inhibited the proliferation, motility, and invasion of HeLa and C33A. Regarding mechanism, FSTL1 plays its role by negatively regulating the BMP4/Smad1/5/9 signaling. Our study has demonstrated the tumor suppressor effect of FSTL1, and these findings suggested a potential therapeutic target and biomarker for cervical carcinoma. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9901576/ /pubmed/36756161 http://dx.doi.org/10.3389/fonc.2023.1100045 Text en Copyright © 2023 Zhao, Chen, Zhu, Miao, Guo, Yuan, Wang, Li and Ning https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhao, Chenjing Chen, Zhongjie Zhu, Li Miao, Yunheng Guo, Jiasen Yuan, Zhiyong Wang, Ping Li, Lian Ning, Wen The BMP inhibitor follistatin-like 1 (FSTL1) suppresses cervical carcinogenesis |
title | The BMP inhibitor follistatin-like 1 (FSTL1) suppresses cervical carcinogenesis |
title_full | The BMP inhibitor follistatin-like 1 (FSTL1) suppresses cervical carcinogenesis |
title_fullStr | The BMP inhibitor follistatin-like 1 (FSTL1) suppresses cervical carcinogenesis |
title_full_unstemmed | The BMP inhibitor follistatin-like 1 (FSTL1) suppresses cervical carcinogenesis |
title_short | The BMP inhibitor follistatin-like 1 (FSTL1) suppresses cervical carcinogenesis |
title_sort | bmp inhibitor follistatin-like 1 (fstl1) suppresses cervical carcinogenesis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901576/ https://www.ncbi.nlm.nih.gov/pubmed/36756161 http://dx.doi.org/10.3389/fonc.2023.1100045 |
work_keys_str_mv | AT zhaochenjing thebmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT chenzhongjie thebmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT zhuli thebmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT miaoyunheng thebmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT guojiasen thebmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT yuanzhiyong thebmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT wangping thebmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT lilian thebmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT ningwen thebmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT zhaochenjing bmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT chenzhongjie bmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT zhuli bmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT miaoyunheng bmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT guojiasen bmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT yuanzhiyong bmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT wangping bmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT lilian bmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis AT ningwen bmpinhibitorfollistatinlike1fstl1suppressescervicalcarcinogenesis |