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Structural insights into catalytical capability for CPT11 hydrolysis and substrate specificity of a novel marine microbial carboxylesterase, E93

INTRODUCTION: CPT11 (Irinotecan; 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin) is an important camptothecin-based broad-spectrum anticancer prodrug. The activation of its warhead, SN38 (7-ethyl-10-hydroxycamptothecin), requires hydrolysis by carboxylesterases. NPC (7-ethyl-10-[...

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Detalles Bibliográficos
Autores principales:	Li, Yang, Rong, Zhen, Li, Zhengyang, Cui, Henglin, Li, Jixi, Xu, Xue-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901791/ https://www.ncbi.nlm.nih.gov/pubmed/36756200 http://dx.doi.org/10.3389/fmicb.2022.1081094

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