Determinants of mortality among hospitalized patients with COVID-19 during first and second waves of the pandemic: A retrospective cohort study from an isolation center in Kano, Nigeria

BACKGROUND: Coronavirus disease 2019 (COVID-19) has emerged as an important cause of morbidity and mortality worldwide. The aim of this study is to identify the clinical predictors of mortality among patients with COVID-19 pneumonia during first and second waves in a treatment center in northwestern...

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Detalles Bibliográficos
Autores principales: Dayyab, Farouq Muhammad, Bashir, Hussain Abdullahi, Sulaiman, Abdulwahab Kabir, Iliyasu, Garba, Hamza, Muhammad, Yakasai, Ahmad Maifada, Nashabaru, Ibrahim, Saidu, Hadiza, Ahmad, Bashir Garba, Dabo, Bashir, Abubakar, Aminu Yusuf, Idris, Ibrahim Musa, Yahaya, Abdulrauf Sani, Ado, Mustapha, Abdurrahman, Ibrahim Sabo, Usman, Hafizu Musa, Bello, Mohammed Kabiru, Jaafar, Jaafar Suleiman, Abdullahi, Anifowose, Alhassan, Abubakar Muhammad, Ahmad, Abdulmalik, Allen, Alika Ehima, Ezekiel, Medu Oghenekevwe, Umar, Muhammad Abdullahi, Abdullahi, Muhammad B., Sulaiman, Sahabi Kabir, Hussaini, Tijjani, Umar, Amina Abdullahi, Tsanyawa, Aminu Ibrahim, Shuaibu, Sabitu Y., Kabo, Nasir Alhassan, Muhammad, Basheer Lawan, Yahaya, Mohammed Nura, Bello, Imam Wada, Rajab, Ashiru, Daiyab, Abdulhakim Muhammad, Kabara, Aminu Faruk, Garko, Muhammad Sule, Habib, Abdulrazaq Garba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901798/
https://www.ncbi.nlm.nih.gov/pubmed/36745658
http://dx.doi.org/10.1371/journal.pone.0281455
Descripción
Sumario:BACKGROUND: Coronavirus disease 2019 (COVID-19) has emerged as an important cause of morbidity and mortality worldwide. The aim of this study is to identify the clinical predictors of mortality among patients with COVID-19 pneumonia during first and second waves in a treatment center in northwestern Nigeria. METHODS: This was a retrospective cohort study of 195 patients hospitalized with COVID-19 between April 2020 to March 2021 at a designated COVID-19 isolation center in Kano State, Northwest Nigeria. Data were summarized using frequencies and percentages. Unadjusted odds ratios and 95% confidence intervals and p-values were obtained. To determine independent determinants of mortality, we performed a stepwise multivariate logistic regression model. RESULTS: Of 195 patients studied, 21(10.77%) patients died. Males comprised 158 (81.03%) of the study population. In the adjusted stepwise logistic regression analysis, age>64 years (OR = 9.476, 95% CI: 2.181–41.165), second wave of the pandemic (OR = 49.340, 95% CI:6.222–391.247), cardiac complications (OR = 24.984, 95% CI: 3.618–172.508), hypertension (OR = 5.831, 95% CI:1.413–24.065) and lowest systolic blood pressure while on admission greater than or equal to 90mmHg were independent predictors of mortality (OR = 0.111, 95%CI: 0.021–0.581). CONCLUSION: Strategies targeted to prioritize needed care to patients with identified factors that predict mortality might improve patient outcome.

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